Hipercalcemia en paciente pediátrica con disgerminoma ovárico: a propósito de un caso / Hypercalcemia in a pediatric patient with ovarian dysgerminoma: A case report

La hipercalcemia asociada a tumores malignos es una entidad poco frecuente en pediatría (0,5-1,3 % de los cánceres pediátricos). Es causada por diferentes mecanismos fisiopatológicos y los síntomas de presentación suelen ser inespecíficos, pero potencialmente graves. Presentamos un caso clínico de una paciente de 12 años con diagnóstico de disgerminoma ovárico bilateral. La enfermedad se presentó con hipercalcemia grave, tratada con hiperhidratación asociada a diuréticos de asa, bifosfonatos y, por último, la resección quirúrgica del tumor, que permitió la resolución definitiva del cuadro. A pesar de tratarse de un trastorno hidroeléctrico poco habitual en pediatría, dada la potencial gravedad de la hipercalcemia, es importante la detección y el tratamiento tempranos, con el fin de evitar complicaciones en el corto y el largo plazo

Hypercalcemia associated with malignant tumors is a rare entity in pediatrics (0.5-1.3 % of pediatric cancers). It responds to different pathophysiological mechanisms and the typical symptoms shown are usually nonspecific, but potentially serious. We present a clinical case of a 12-year-old patient with a bilateral ovarian dysgerminoma who was diagnosed with severe hypercalcemia at the onset, which required hyperhydration associated with loop diuretics, bisphosphonates and, eventually, the tumor resection surgery that allowed the final resolution of the clinical picture.Despite being a rare hydroelectric disorder in pediatrics, given the potential severity of hypercalcemia, early detection and treatment are important in order to avoid potential short- and long-term complications.

Disgerminoma puro de ovario: presentación de dos casos

Siendo el Disgerminoma el tumor de células germinales más común en mujeres jóvenes, es también de los menos frecuentes de los tumores de ovario, oscilando su incidencia en Colombia del 0.48 a 0.55 por ciento. Se presentan dos casos atendidos en el Departamento de Ginecología y Obstetricia del Hospital Universitario Metropolitano en un período de 10 años

Brainstem germinoma presenting as intermittent apnoea: a rare entity: report of one patient and review of literature.

A 17-year-old man who had repeated pneumonia and presented with intermittent apnoea was described clinically and pathologically. Neurological examination and computed axial tomography revealed a calcified mass over the lower brainstem. Neurological intervention was done with removal of the tumour and the pathological section showed the classical picture of germinoma. The patient was given irradiation treatment afterwards and he was weaned off the respirator within a week. Unfortunately, he died because of recurrent chest infection after a long hospital admission of 92 days. Reviewing the literature showed the rarity of the germinoma at the brainstem location.

Disgerminoma do ovario / Dysgerminoma of the ovary

Uma atualizacao sobre disgerminoma do ovario atraves de uma revisao de literatura e feita neste artigo. Caracteristicas clinicas e anatomopatologicas sao definidas, e o tratamento atual e enfatizado.