Anal intraepithelial neoplasia associated with high-grade vulva injury (usual-type vulvar intraepithelial neoplasia): surgical treatment with cutaneous flap advancement

The aim of the present article is to report the case of a young patient with bowenoid papulosis who was a carrier of other sexually-transmitted infections (STIs), such as HIV and high-grade vulva lesion (usual-type vulvar intraepithelial neoplasia, VIN), and to demonstrate the strategy used to manage the case, as well as to discuss important issues regarding the standardization of intraepithelial lesions. (AU)

Co-existence of extramammary Paget's disease and Bowen's disease of vulva.

Extramammary Paget’s disease and Bowen’s disease are histologically similar and immunohistochemistry is often required to make the diagnosis. We present a case of vulval Paget’s disease with Bowen’s disease in an elderly female. Strong positivity for cytokeratin 7, anti CAM 5.2, carcinoembryonic antigen (CEA) and periodic acid‑Schiff (PAS) stain in clitoral, left labial and interface regions of the vulvectomy specimen confirmed the diagnosis of Paget’s disease (PD) while positive staining for p63 in the right labial and interface regions helped in establishing the diagnosis of concurrent Bowen’s disease (BD).

Bowen's disease on finger: A diagnostic and therapeutic challenge.

Bowen's disease commonly presents as a solitary asymptomatic plaque involving head and neck region or lower limbs. We present a case of a sixty seven-year-old man with an itchy, oozy, crusted solitary plaque on the right ring finger of eighteen months duration with histopathology consistent with Bowen's disease. The lesion was initially treated with topical 5% imiquimod but due to relapse and inadequate response to a second course, complete surgical excision followed by full thickness skin grafting was done. Recurrence after about 6 months in the form of a small papule adjacent to the initial site was also treated with excision. This report highlights the potential of Bowen's disease to mimic more common dermatoses and a high index of suspicion, supported by histopathology, is required to diagnose and treat it without delay, which in turn may require a multimodality approach. We also reviewed the current literature on the same.

Neoplasias malignas cutânea: estudo epidemiológico / Cutaneous malignant neoplasias: study epidemiologist

Fundamentos: O câncer no mundo, atualmente é o de pele. Sua incidência vem aumentando significativamente, porém o número de casos exatos não é conhecido, especialmente no Brasil. Objetivo: Atualização do levantamento estatístico de câncer de pele feito no Serviço de Dermatologia da Faculdade de Medicina do ABC em 1987. Material e Métodos: Em um levantamento de 50.000 prontuários correspondentes ao período de janeiro de 1987 a Dezembro de 1998,realizou-se um estudo retrospectivo de 1040 pacientes que apresentavam 1194 neoplasias malignas de pele, diagnosticadas por exame anatomopatológico e posteriormente submetidas a tratamento cirúrgico no Serviço de Dermatologia da Faculdade de Medicina do ABC. Resultado: O tumor de pele mais encontrado foi o Carcinoma basocelular (CBC) 73,3%, seguido pelo carcinoma espinocelular (CEC) 18,8%, doença de Bowen 4,86% e melanoma 3,0%. Conclusões: Os resultados encontrados foram compatíveis com os relatados na literatura, exceto pelo predomínio do sexo feminino nos casos de carcinoma basocelular em nosso estudo.

Papulose Bowenóide: um caso clinico / Bowenoide papulosis: a clinical case

Descrevemos o caso clínico de um doente com papulose bowenóide localizada na pele da prega inguino-escrotal direita, tendo sido feita comprovaçao histopatológica e identificaçao de Papilomavírus Humano tipo 16 em material de biópsia.

Papulosis bowenoide génito-anal y carcinoma de margen anal / Genito-anal bowenoid papulosis and carcinoma at the perianal region

Presentamos el caso de una paciente de 42 años de edad con numerosas lesiones papulosas de distribución génito-anal y una sobreelevada y ulcerada en región perianal. El diagnóstico clínico fue de papulosis bowenoide (PB) génito-anal con un área de presumible transformación neoplásica. La histopatología demostró la presencia de una papulosis bowenoide y un carcinoma pavimentoso. Se decide una extirpación de la lesión con margen oncológico y en una segunda etapa el tratamiento de la PB con interferón alfa 2

Fine needle aspiration biopsy in the diagnosis of ocular pathology

In this work, 2 groups of cases were subjected to this procedure to evaluate its reliability and to indicate when FNAB is advantageous over the conventional diagnostic procedures. The first group included 10 eyes, 7 of them had retinoblastoma and the others had Bowen's disease. FNAB was taken before the enucleation or the excision biopsy and compared with the histopathological diagnosis [histopathological control]. The second group included 11 eyes, 4 of them had lid masses, 3 proved to be inflammatory in nature and 1 malignant [metastasis]. One case of proptosis was suspicious to be malignant and proved to be a chronic inflammatory mass. The other 6 eyes had intraocular lesions. One with a chronic inflammatory limbal mass, 1 with toxocariasis, 2 with leukocoria [1 retinoblastoma and 1 chronic non-granulomatous inflammation]. In the last 2 eyes FNAB proved the infective nature of a case of chronic endophthalmitis and a spindle cell melanoma in the other. It is concluded that FNAB is an effective and reliable method in the investigation of ocular pathology

Doença de Bowen da regiäo perianal: análise de três casos

Os autores relatam três casos de Doença de Bowen, de localizaçäo perianal, sendo que dois apresentaram também lesöes vulvares e haviam sido submetidos anteriormente a vulvectomia simples por CARCINOMA "IN SITU". As lesöes perianais evoluiram assintomaticamente e uma vez estabelecida a suspeita diagnóstica, foram excisadas e submetidas a exame histopatológico que confirmou a natureza neoplásica das mesmas. Foram analisados o quadro clínico, etiologia, diagnóstico, diagnóstico diferencial e tratamento, comparando-os com os da literatura

Papulosis bowenoide genital / Bowenoid papulosis of genitalia

Se estudiaron 5 hombres y 2 mujeres con papulosis Bowenoide genital, con edades entre 17 y 48 anos. Las lesiones tuvieron una evolucion de un mes a diez anos y consistieron en papulas a veces pigmentadas, confluentes, asintomaticas en el hombre y pruriginosas en la mujer, de dificil diagnostico clinico y que afectaban el grande, el cuerpo del pene, los labios mayores, el rafe anal y las regiones inguinales. El diagnostico definitivo se establecio por la biopsia la cual mostro carcinoma intraepidermico de tipo Bowen. En los 4 pacientes, en quienes se practico estudio ultraestructural no se demostraron particulas virales. La PBG es probablemente una enfermedad de Bowen con caracteristicas clinicas especiales, en personas jovenes. La escicion local de las lesiones o la aplicacion topica de 5 - fluoracilo son tratamientos satisfactorios