Enfermedad de Von Economo: Caso clínico / Lethargic Encephalitis: Report of one case

Lethargic encephalitis (LE) is a Central Nervous System disorder following an upper respiratory tract infection, characterized by sleep disturbances, clinical symptoms corresponding to basal ganglia involvement and in some cases, neuropsychiatric sequelae. We report a 18-year-old mole with a history of sinusitis treated with azithromycin, two weeks before, presenting with fever, headache, confusion and myoclonus. Urine analysis was positive for cannabis. Cerebro spinal fluid analysis showed mononuclear pleiocytosis (109xmm³) and an increase in protein concentration ofl.6 g/dl. Forty eight hours after admission, the patient required mechanical ventilation and subsequently a status epilepticus appeared. Ten days later, fever, rigidity and resting tremor appeared. A magnetic resonance imaging showed hyperintensities in FLALR sequence in the right insular cortex. The patient continued with extreme rigidity, catatonia and mutism. Considering the possibility ofa LE, methyl prednisolone 1 g/day was administered for five consecutive days followed by prednisone 40 mgl day, observing a dramatic improvement of rigidity and tremors.

El triste final prematuro de la pianista chilena Rosa Renard Artigas 1894-1949 / The sad and premature ending of the chilean pianist Rosa Renard Artigas 1894-1949

Se analiza en forma restrospectiva la enfermedad neurológica que terminó prematuramente con la vida de Rosa Renard Artigas a los 55 años de edad. Ella fue conocida y admirada internacionalmente como una notable pianista y su muerte ocurrió 4 meses después de su triunfo presentación en el Carnegie Hall de Nueva York. El diagnóstico de encefalitis letárgica hecho por su médico personal aparece muy cuestionable, dados el comienzo subagudo y las manifestaciones neurológicas que son muy discordantes con lo descrito como signos característicos de la encefalitis letárgica por Von Economo. En cambio, la probabilidad de una posible enfermedad de Creutzfeldt-Jakob es altamente sugerente en este caso