RESUMO
Abstract: BACKGROUND: Patients with systemic lupus erythematosus seem to belong to different serological and clinical subgroups of the disease. Genetic background can cause the appearance of these subgroups. OBJECTIVE: To determine whether Brazilian patients who have systemic lupus erythematosus and Raynaud's phenomenon differ from those who do not. METHODS: Retrospective analysis of 373 medical records of systemic lupus erythematosus patients studied for demographic, clinical and serological data. A comparative analysis was performed of individuals with and without RP. RESULTS: There was a positive association between Raynaud's phenomenon and age at diagnosis (p=0.02), presence of anti-Sm (p=0.01) antibodies and anti-RNP (p<0.0001). Furthermore, a negative association was found between Raynaud's phenomenon and hemolysis (p=0.01), serositis (p=0.01), glomerulonephritis (p=0.0004) and IgM aCL (p=0.004) antibodies. CONCLUSION: Raynaud's phenomenon patients appear to belong to a systemic lupus erythematosus subset with a spectrum of clinical manifestations located in a more benign pole of the disease.
Assuntos
Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Lúpus Eritematoso Sistêmico/fisiopatologia , Doença de Raynaud/fisiopatologia , Anticorpos Antinucleares/análise , Brasil , Lúpus Eritematoso Sistêmico/imunologia , Lúpus Eritematoso Sistêmico/patologia , Prontuários Médicos , Estudos Retrospectivos , Doença de Raynaud/imunologia , Doença de Raynaud/patologia , Estatísticas não ParamétricasRESUMO
El síndrome antisintetasa es una entidad poco frecuente, incluida dentro del grupo de las miopatías inflamatorias idiopáticas. Se caracteriza por la presencia de anticuerpos antisintetasa, fiebre, miositis, enfermedad pulmonar intersticial, poliartritis, fenómeno de Raynaud y manos de mecánico.
The antisynthetase syndrome is a rare condition that has been included in the group of idiopatic inflammatory skeletal muscle disease. The presence of antisynthetase autoantibody, fever, myositis, intersticial lung disease, polyarthritis, Raynaud´s phenomenon and mechanic´s hands represent the main characteristics of antisynthetase syndrome.
Assuntos
Humanos , Autoanticorpos/análise , Doenças Autoimunes/diagnóstico , Doença de Raynaud/imunologia , Doenças Musculares/imunologia , Doenças Pulmonares Intersticiais/imunologia , SíndromeRESUMO
Se estudian 32 pacientes y un grupo control de 10 personas con un protocolo que consta de : Cínica, inmunología y capilaroscopía. Esta última es una técnica de visualización in vivo de los capilares del lecho ungueal a traveés de una lupa estereos-cópica. Se analiza edad de aparición, correlación de los tres items del protocolo y enfermedad de base en Raynaud secundario. Los pacientes se dividieron en: Raynaud primario (7), Raynaud secundario (19) y Raynaud indeterminado (4). La sensibilidad del presente estudio para el diagnóstico diferencial fue del 81,3 por ciento. Además se analiza la alteración de la morfologá capilar y la injuria capilar (presencia de hemorragias) a nivel capilaroscópico