Microbiological profile of orbital abscess.

Background: Knowledge of the culture and sensitivity pattern is necessary, for the institution of appropriate empirical antibiotic therapy in orbital abscess. Objective: The objective of this study is to describe culture and sensitivity patterns of specimens from the orbit and surrounding structures. Materials and Methods: Retrospectively the medical records of 56 cases of orbital abscess were reviewed. Results: Cultures were positive in 38/56 (68.8%) orbital specimens and the organisms included Staphylococcus aureus 18, Streptococci 7, Pseudomonas aeruginosa 3, 2 each of Enterobactersp, Escherichia coli, Proteus mirabilis, Acinetobacter sp. and 1 each of Actinomyces israelii, Diptheroids, Coagulase negative Staphylococcus, Citrobacter freundii, Methicillin-resistant S. aureus and Enterococcus faecalis. Four had polymicrobial infection. Culture of purulent nasal discharge, swabs taken from foci of infection on the face, and blood cultures were done in 26/56, and positive cultures were obtained in 16/26 (61.5%) specimens. In 12 patients, there was a concurrence in the organism cultured from the orbit and from cultures from other sites. Gram-negative organisms were associated with increased ocular morbidity. Conclusion: Gram-positive cocci, especially S. aureus are the most common organisms isolated from orbital abscesses. Infections by Gram-negative organisms were associated with more complications. Empirical intravenous antibiotic therapy should have a broad spectrum of activity effective against a wide range of Staphylococcal organisms and Gram-negative bacilli.

Disseminated orbital actinomycetoma: A case report.

Mycetoma is a chronic granulomatous infection. Lower extremities are commonly involved. A 20-year-old male came with complaints of multiple sinuses on scalp, left eyelid swelling with a sinus and dystopia, since one year. On examination there was relative proptosis in left eye of 2 mm. Computed tomography scan showed soft tissue swelling of the pre-septal area of the left upper eyelid with orbital involvement. Magnetic resonance imaging showed increased left orbital volume and evident dystopia. Microbiology testing of the erosive scalp and lid lesions showed genus Nocardia, suggestive of actinomycetoma. This case is presented as it shows an unusual involvement of the orbit.

Orbital abscess secondary to acute dacryocystitis: case report / Abscesso orbitário secundário à dacriocistite aguda: relato de caso

Acute dacryocystitis usually induces preseptal infection. In rare instances the infection that is confined to the lacrimal sac can extend to the orbital contents resulting in orbital cellulitis. We present a case of intraconal abscess secondary to acute dacryocystitis and review the literature of orbital cellulitis resulting from acute lacrimal sac infection.

A dacriocistite aguda comumente evolui para infecção pré-septal. Raramente a infecção localizada no saco lacrimal pode estender-se ao conteúdo orbitário resultando em celulite orbitária. Apresentamos um caso de abscesso orbitário intraconal secundário à dacriocistite aguda e uma revisão de literatura de celulite orbitária causada por infecção aguda do saco lacrimal.

Mucormicosis rino-orbito-cerebral: experiencia en doce años / Rhino-orbital-cerebral mucormycosis: a twelve-year experience

Introducción: La mucormicosis rino-órbito-cerebral (MROC) es una infección poco frecuente y de alta mortalidad, causada por hongos pertenecientes al orden Mucorales. Afecta excepcionalmente a individuos sanos, siendo mucho más frecuente que se produzca en sujetos inmunodeprimidos. Objetivo: Presentar la casuística de 12 años en mucormicosis del Hospital Barros Luco Trudeau. Material y método: El estudio incluye a 16 pacientes con MROC atendidos en el Hospital Barros Luco Trudeau, entre los años 1993 y 2004, detallando características clínicas de presentación de la enfermedad, procedimientos diagnósticos y terapéuticos realizados, efectos adversos de la terapia y mortalidad. Resultados: Sólo un paciente de la serie era inmunocompetente. El síntoma más frecuente fue dolor facial y el hallazgo más frecuente al examen físico, fue la presencia de una escara negra o grisácea en la mucosa nasal. El estudio micológico directo fue positivo en 11 casos, mientras que el cultivo de hongos resultó positivo sólo en 10 pacientes. Del total de pacientes, 15 recibieron tratamiento combinado de cirugía y terapia antifúngica intravenosa (anfotericina B). Once pacientes fueron debridados por medio de una cirugía abierta (8 maxilectomías parciales y 3 totales). Cuatro pacientes fueron debridados mediante una técnica endoscópicay todos ellos necesitaron mßs de un procedimiento. Discusión y Conclusión: Se discuten las causas y el hallazgo más consistente al examen físico y la conducta del hospital ante los casos sospechosos. También se comenta la importancia de las imágenes, el compromiso orbitario, la invasión cutánea y especialmente el tratamiento médico y quirúrgico. Se destaca la sobrevida general de la serie que fue de 62,5 por ciento

Introduction: Rhino-orbital-cerebral mucormycosis (MROC) is a rare, high mortality infection, produced by fungi belonging to the order Mucorales. It exceptionally affects healthy individuals, being much more prevalent in immunocompromised patients. Aim: To present the 12year experience in mucormycosis at the Barros Luco Trudeau Hospital. Material and Method: This study involves 16 MROC patients that were treatedatthe Barros Luco Trudeau Hospital between 1993 and 2004. We present detailed clinical characteristics of the disease, diagnostic and therapeutic procedures performed, adverse therapy effects and mortality. Results: Only one of the patients was immunocompetent. The most frequent symptom was facial pain and the most frequent finding at physical examination was a black or grayish scab on the nasal mucosa. Direct mycological study was positive in 11 cases, whereas fungal culture was positive in only 10 patients. Of all patients, 15 received combined surgical and intravenous antifungal therapy (amphotericin B). Eleven patients had debridement by open surgery (8 partial and 3 total maxillectomies). Four patients had endoscopic debridement; all of them required more than one procedure. Discussion and Conclusion: Possible causes are discussed as well as the more consistent findings at physical examination and the institution behavior when suspecting a case. In addition, imaging importance, orbital involvement, cutaneous invasion and medical and surgical treatments are discussed. The series survival rate of 62 percent is underscored

Complicaciones de rinosinusitis aguda en niños del Hospital Sótero del Río / Complications of acute rhinosinusitis in children at Sótero del Río Hospital

Introducción: La rinosonusitis aguda (RSA) es frecuente en niños, respondiendo bien a tratamiento médico en la mayoría de los casos. Sin embargo puede presentar complicaciones graves a nivel orbitario e intracerebral. Objetivo: Evaluaria frecuencia, describirias características clínicas, evaluare! tratamiento y evolución de la rinosinusitis aguda complicada, en niños del Hospital Sótero del Río. Material y método: Estudio retrospectivo-descriptivo realizado en el Hospital Sótero del Río, utilizando fichas clínicas de pacientes ingresados desde enero de 2002 hasta julio de 2007, con diagnóstico de RSA complicada. Resultados: Se incluyeron 27 pacientes con diagnóstico presuntivo de RSA complicada: 30 por ciento con celulitis preseptal aislada, 36 por ciento celulitis postseptal, 26 por ciento absceso subperióstico y 8 por ciento complicaciones intracraneales. La edad promedio fue 4.53 años (4 meses-13 años); 56 por ciento sexo masculino y 44 por ciento sexo femenino; promedio de días hospitalizados 7,24 días (2-19 días); total de días con tratamiento antibiótico 20,2 días (9-38 días); el cultivo microbiológico fue positivo en 25 por ciento de los pacientes con tratamiento quirúrgico (Staphylococcus epidermidis). No existió compromiso visual al alta en ninguno de los pacientes. Conclusión: La complicación más frecuente de RSA fue la orbitaria (92 por ciento) similar a lo descrito en la literatura. El seno etmoidal, maxilar y frontal fueron frecuentemente comprometidos. La edad de presentación de complicación de RSA fue levemente menor a lo descrito en la literatura. Se encontró predominio del género masculino, aunque en los abscesos subperiósticos predominó el sexo femenino. No se encontró relación directa entre la gravedad de RSA y los valores de proteína C reactiva (PCR) y leucocitosis. La mayoría de los abscesos subperiósticos se manejaron médicamente, teniendo la mitad de ellos más de 9 años. Sólo un paciente presentó complicación orbitaria y encefálica...

Introduction: Acute rhinosinusitis (RSA) is frequent in children. Although in most cases responds well to medical treatment, it could result in serious orbital and intracranial complications. Aim: To assess the frequency, describe the clinical characteristics and evaluate treatment and evolution of acute rhinosinusitis in children at Sótero del Rio hospital. Material and Method: Retrospective - descriptive study of clinical data from Sótero del Rio hospital between Jan 2002 and July 2007, involving patients with a diagnosis of complicated RSA. Results: Data from 27 patients were included in this study, all with presumptive RSA complications: 30 percent had isolated preseptal cellulitis, 36 percent had postseptal cellulitis, 26 percent had subperiostal abscesses, and 8 percent had intracranial complications. The average age of patients was 4,53 years (4 months-13 years old); 56 percent were males and 44 percent were females; hospitalization was in average 7,24 days (2 -19 days), the average number of days on antibiotic treatment was 20,2 (9 -38 days); microbiologic culture was positive in 25 percent of patients with surgical treatment (Staphylococcus epidermidis). None of the patients had visual complications when they were discharged from the hospital. Conclusion: The most frequent RSA complication was orbital (92 percent of complications), similar to what is reported in the literature. Ethmoidal, maxilar and frontal sinuses were more often involved. RSA complications presented at a slightly younger age than reported in the literature. More often males were affected, but subperiostal abscesses were more common in females. There was no direct relation between RSA seriousness and C-reactive protein or leukocitosis. Most subperiostal abscesses were medically treated; more than half of these patients were older than 9 years old. Only one patient presented both orbital and intracranial complications

Rhino-orbito-cerebral mucormycosis. A retrospective analysis of clinical features and treatment outcomes.

OBJECTIVE: The conventional management of rhino-orbito-cerebral (ROC) mucormycosis includes control of metabolic abnormality, administration of amphotericin B and surgery that spans simple sinus clearance, radical debridement and orbital exenteration. Recent literature includes anecdotal descriptions of successful treatment with conservative management of involved orbits. We evaluated the clinical features and outcome of treatment for the different stages of ROC mucormycosis. METHOD: In this retrospective case series, 34 case records of patients with a histopathological diagnosis of ROC mucormycosis treated between 1992 and 2000 were reviewed. Three clinical stages and three treatment groups were identified. Patients with limited sino-nasal disease (Clinical stage I) underwent sino-nasal debridement (Treatment group A). Patients with limited rhino-orbital disease (Clinical stage II) underwent either sino-nasal debridement alone (Treatment group A) or orbital exenteration in addition to sino-nasal debridement (Treatment group B). Patients with rhino-orbito-cerebral disease (Clinical stage III) did not undergo any surgical procedure (Treatment group C). Thirty-three patients received intravenous amphotericin B. Outcome for each group was measured as "Treatment success" (disease free, stable patient with metabolic abnormality under control) and "Treatment failure" (progression of disease with worsening general condition or mortality due to the disease). RESULTS: Uncontrolled diabetes in 30 (88.2%) of 34 patients was the commonest underlying disease and 16 (53.3%) of 30 diabetics had ketoacidosis. Chronic renal failure (n = 4), hepatic disease (n = 3) and idiopathic thrombocytopenia (n = 1) were the other underlying diseases. Eleven patients had stage I disease, 16 patients had stage II disease and seven patients had stage III disease. All 11 patients with stage I disease received treatment A; of 16 patients with stage II disease, 7 received treatment A and the remaining with stage III disease received treatment B; 7 patients with stage II disease received treatment C. Ten of 11 patients (91%) with stage I disease had treatment success. In patients with stage II disease, 7 of 7 (100%) with treatment A and 1 of 9 (11.1%) with treatment B had treatment success. All seven patients with stage III disease had treatment failure. CONCLUSION: Debridement of the sinuses is necessary in all cases of rhino-orbito-cerebral mucormycosis. Diagnosis in the early stage needs a high degree of suspicion. There is a definite role for retention of orbits in patients whose metabolic derangement is rapidly controlled and orbital involvement is non-progressive.

Inflamación aguda de la órbita. Celulitis orbitaria / Acute orbital inflammation. Orbital cellulitis

Se hace la revisión de 72 casos de celulitis orbitaria, estudiados en el Hospital "Luis Sánchez Bulnes" de la Asociación Para Evitar la Ceguera en México, en un período de 14 años, de 1982 a 1996, analizando la prevalancia, etipatogenia, curso del padecimiento, respuesta al tratamiento y complicaciones presentadas

Clostridium perfringens endophthalmitis and orbital cellulitis

Endogenous endophthalmitis in healthy adults is extremely uncommon. Moreover, endogenous Clostridium perfringens infection of the intraocular structures is rare. We report a healthy adult male who developed sudden loss of vision. Eye examination revealed evidence of endophthalmitis. The clinical course was complicated by orbital cellulitis. Blood cultures grew C. perfringens. This case confirms the fact that endogenous endophthalmitis may rarely occur in healthy adults. Prompt diagnosis and early treatment may prevent loss of vision and other serious complications