RESUMO
We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment. A 5-year-old girl was diagnosed preB cell Acute Lymphoblastic Leukemia (ALL). She received chemotherapy according to the previously described modified St. Jude total therapy studies XIII. Five days after the fourth dose of vincristine, she presented with bilateral ptosis. Neurological examination revealed bilateral ptosis, and complete external opthalmoplegia with normal pupillary and corneal reflexes. She received 3.8 mg cumulative dose of vincristin before development of ptosis. A neuroprotective and neuroregenerative treatment attempt with pyridoxine and pyridostigmine was initiated. The bilateral ptosis markedly improved after 7 days of pyridoxine and pyridostigmine treatment and completely resolved after two weeks. The both agents were given for 3 weeks and were well tolerated without any side effects. During the follow up period we did not observe residue or recurrence of the ptosis.
Assuntos
Antineoplásicos Fitogênicos/efeitos adversos , Blefaroptose/induzido quimicamente , Pré-Escolar , Inibidores da Colinesterase/uso terapêutico , Doenças dos Nervos Cranianos/induzido quimicamente , Feminino , Humanos , Oftalmoplegia/induzido quimicamente , Polineuropatias/induzido quimicamente , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Brometo de Piridostigmina/uso terapêutico , Piridoxina/uso terapêutico , Vincristina/efeitos adversos , Complexo Vitamínico B/uso terapêuticoAssuntos
Adulto , Gluconato de Antimônio e Sódio/administração & dosagem , Doenças dos Nervos Cranianos/induzido quimicamente , Relação Dose-Resposta a Droga , Esquema de Medicação , Nervo Glossofaríngeo/efeitos dos fármacos , Humanos , Injeções Intramusculares , Injúria Renal Aguda/induzido quimicamente , Leishmaniose Visceral/tratamento farmacológico , Masculino , Paralisia/induzido quimicamente , Nervo Vago/efeitos dos fármacosRESUMO
Very few cases of the "intermediate neurotoxic syndrome", a type of neurotoxic effect or organophosphate compound have been reported in the literature. We are reporting a case that developed the clinical features of such type of neurotoxic effect after 55 hours of taking the organophosphorus compound.