RESUMO
Malignant atrophic papulosisis is a rare, multisystem obliterative vasculopathy of unknown etiology, occasionally involving the cranial nerve. We describe the first case of malignant atrophic papulosisis with cranial nerve and peripheral nerve involvement in China. A 47-year-old woman presented to our hospital with atrophic porcelain white papules over the trunk and extremities, numbness in the right calf, vision decrease and impaired movement of the right eye. She was diagnosed with malignant atrophic papulosisis, based on characteristic symptoms and histopathologic examination. The patient was treated with dipyridamole and aspirin for 9 months, but later died of gastrointestinal hemorrhage. We reviewed currently available case reports on cranial nerve involvement in malignant atrophic papulosisis and emphasized the importance of skin biopsy in diagnosing this disease.
.Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Doenças dos Nervos Cranianos/patologia , Papulose Atrófica Maligna/patologia , Doenças do Sistema Nervoso Periférico/patologia , Biópsia , Doenças dos Nervos Cranianos/tratamento farmacológico , Evolução Fatal , Papulose Atrófica Maligna/tratamento farmacológico , Doenças do Sistema Nervoso Periférico/tratamento farmacológico , Pele/patologiaRESUMO
Bone involvement in primary systemic amyloidosis is rare. Intracranial involvement in primary amyloidosis has not been reported so far. We report two cases of bone involvement in primary amyloidosis. The first patient also had combined deficiencies of factor IX and XII, while the second patient had associated intracranial involvement and XIIth cranial nerve palsy. Both these cases are unique in that, destructive bone lesions with intracranial involvement and combined factor deficiencies have not been reported in primary amyloidosis previously.
Assuntos
Adulto , Idoso , Amiloidose/complicações , Doenças Ósseas/tratamento farmacológico , Doenças dos Nervos Cranianos/tratamento farmacológico , Dexametasona/uso terapêutico , Feminino , Humanos , Interferons/uso terapêutico , Masculino , Pessoa de Meia-IdadeAssuntos
Comorbidade , Doenças dos Nervos Cranianos/tratamento farmacológico , Dilatação Patológica , Feminino , Glucocorticoides/uso terapêutico , Humanos , Hipopituitarismo/epidemiologia , Angiografia por Ressonância Magnética , Pessoa de Meia-Idade , Quiasma Óptico/patologia , Prednisolona/uso terapêutico , RecidivaRESUMO
El manejo de las polineuropatías agudas desmielinizantes está aún en discusión, especialmente el síndrome de Guillain-Barré. El empleo de inmunoglobulina con molécula intacta por vía endovenosa y los efectos benéficos observados en coincidencia con su uso, se ilustran en tres pacientes varones de 10 años 6 meses, 11 años 3 meses y 12 años 10 meses, respectivamente, todos ellos severamente afectados -los dos primeros con compromiso de los músculos respiratorios-, que fueron tratados con dosis altas, de 300 a 400 mg x kg x día durante cuatro días, con rápida recuperación clínica, manifestada por apoyo ventilatorio de corta duración en los casos que lo requirieron y reinicio de la marcha espontánea en menos de 15 días después del tratamiento
Assuntos
Humanos , Masculino , Criança , Doenças dos Nervos Cranianos/tratamento farmacológico , Doenças Desmielinizantes/tratamento farmacológico , Imunoglobulinas Intravenosas/uso terapêutico , Polirradiculoneuropatia/tratamento farmacológicoRESUMO
The clinical course of cryptococcal meningitis in AIDS shows some important differences from the features of the illness in non-AIDS patients. Complications such as raised intracranial pressure and visual impairment that are recognised in non-AIDS patients may be less frequent in those with AIDS. Persistent intracranial hypertension should be managed actively to prevent visual impairment. In AIDS patients; in whom ventriculo-peritoneal shunts carry additional risks; acetazolamide can be used successfully to lower the CSF pressure and prevent visual loss