RESUMO
Discutem-se aqui as formas de encaminhamento de pacientes ao Hospital Adauto Botelho, localizado em Cariacica, Espírito Santo. A pesquisa se deu por meio de prontuários médicos datados desde a inauguração em 1954 e de depoimentos de pessoas que trabalharam lá durante a segunda metade do século XX. Foram analisados 102 prontuários e entrevistadas quatro pessoas. A pesquisa dos prontuários mostra forte inserção da Chefatura de Polícia no processo de internação. As falas dos entrevistados reiteram esse ponto, mostrando também a longa duração das internações. São as histórias de vida dos internos que dão o tom deste trabalho. Conclui-se, a partir delas, que o Hospital Adauto Botelho, mais que uma instituição de tratamento, era um espaço de confinamento.
This paper discusses the procedures for referring patients to Adauto Botelho Hospital, in Cariacica, Espírito Santo state, Brazil. The research is based on the medical records since its inauguration in 1954 and statements by people who worked there in the second half of the twentieth century. One hundred and two records were analyzed and four people were interviewed. The records revealed the active involvement of the Chief of Police in hospitalizations. The interviews corroborate this, while also showing the long duration of the hospitalizations. The tone of the paper is set by the life stories of the people hospitalized there. The conclusion is that this hospital served not so much for treatment as for confinement.
Assuntos
Animais , Proteínas de Neoplasias/metabolismo , Elongação Traducional da Cadeia Peptídica , RNA Polimerase I/metabolismo , Fatores Genéricos de Transcrição , Transcrição Gênica , Fatores de Elongação da Transcrição , Fatores de Transcrição/metabolismo , Sequência de Aminoácidos , DNA Polimerase II/metabolismo , Detergentes/metabolismo , Eletroforese em Gel de Poliacrilamida , Dados de Sequência Molecular , Sarcosina/análogos & derivados , Sarcosina/metabolismo , XenopusRESUMO
Epstein-Barr Virus [EBV] has a great co relationship with human malignancies such as gastric carcinoma. Synonymous codon investigations in viruses could help designing vaccine, to generate immunity. Codon Adaptation Index [CAI] has measured translation elongation rate, among the highly expressed genes. The aim of this study was: usage of "CAI" to measure translation efficiency to know how fast EBV-GD1 could produce its proteins. The complete genomic sequences of human herpes virus 4 strain GD1 have retrieved from http://www.ncbi.nlm.nih.gov/sites/gquery [GenBank accession no. AY961628] to extract all protein-coding genes. The sequences have analyzed with DAMBE software. The results have shown that CAI values for the EBV-GD1 genes were 0.76356 +/- 0.02957. The highest and lowest CAI values were 0.82233 and 0.68321 respectively. The results have shown that highly expressed genes mostly had more codon usage bias than low expressed genes. The results provide and introduce not only a system, but also the principles in order to understand the pathogenesis and evolution of EBV-GD1, to open a window, in order to make a better product or vaccine to challenge with the virus