Epidermodysplasia verruciformis: An unusual malignant transformation.

Epidermodysplasia verruciformis (EV) is a rare, life-long heritable disease caused due to a unique susceptibility to human papilloma virus. The disseminated verrucous lesions and pityriasis versicolor-like lesions persist from early childhood and can transform into a cutaneous malignancy in a fourth of patients. Malignant transformation into syringoid eccrine carcinoma (SEC) has been reported only once so far. SEC is an extremely invasive, rare, locally destructive, slowly growing adnexal tumor. We hereby report the association of EV with SEC in a 29-year-old male.

Invasive squamous cell carcinoma of the eyes in patients with epidermodysplasia verruciformis

We described 3 male patients with epidermodysplasia verruciformis seen in the Department of Dermatology and Venereology, Baghdad Teaching Hospital; their ages were 25, 30 and 34 years subsequently. They developed frequent multiple basal and squamous cell carcinoma, all of them had periorbital squamous cell carcinoma that invaded the orbit and ended with enucleation of their eyes. All available therapeutic measures failed to inhibit the progressiveness of these tumors. Great awareness and early management must be performed regarding any periorbital lesion in epidermodysplasia verruciformis patients

Lesäo ocular em epidermodisplasia verruciforme / Ocular lesion in epidermodysplasia verruciformis

Descriçäo de um caso de epidermodisplasia verruciforme com acometimento ocular. A tumoraçäo corneana existente foi ressecada. Näo houve recidivas mesmo três anos após a intervençäo. Estudo histopatológico é apresentado. Ao que sabemos, trata-se do primeiro caso onde é descrita a associaçäo entre tal displasia e carcinoma espinocelular córneo-conjuntival in situ