RESUMO
Nephrotic syndrome [NS] is characterized by significant protein loss in urine. Coagulation factors are expected to be lost in urine among the other proteins. Several studies on coagulation factors in patients with NS revealed changes in the various factors concerned with coagulation. This study included 30 patients with NS and 10 healthy subjects as control. All patients were subjected to renal biopsy to know the underlying pathological lesion. Beside the baseline investigations, the activities of coagulation factors IX and X were assayed. The results of this study showed that most of patients [except those with minimal lesion glomerulopathy] had significant increase in the activity of both factors IX and X [p < 0.05] with a significant decrease in clotting time. The cause of this increase in the activity may be due to increased synthesis by the liver which exceeds the rate of urinary loss. These changes in coagulation may have their effect on the course of the underlying renal disease