Simultaneous vaccination of combined inactivated respiratory virus vaccine [pneumo-3] withrift valley fever in sheep

A total of twelve seronegative sheep against Infectious Bovine Rhinotracheities [IBR], Bovine Viral Diarrhoea [BVD], Parainfluinza-3 [a] [PI-3] and Rift Valley Fever [RVF] was randomly divided into four groups. One group received [pneumo-3] vaccine alone, another one simulatenously received pneumo-3 and Rift Valley [RVF] vaccine. The third group received RVF alone and the fourth group served as a non-vaccinated control. No side effects or clinical reaction or disease syndrome could be detected in any of the vaccinated groups. All tested animals remained clinically normal throughout an observed period of 6 weeks post vaccination. Very satisfactory serological responses were detected in animals simultaneously inoculated, with both vaccines as well as in animals soldy vaccinated with either vaccine. No significant differences could be found in IBR, BVD and PI-3 serum neutralizing antibody titres of all groups of vaccinated animals also there is no significant difference could be found in RVF serum neutralizing antibody titre. The results clearly indicated the safety and efficacy of simultaneous inoculation of sheep with pneumo-3 with RVF vaccines without impairing the response to individual vaccines and no antagonism between the vaccination penumo-3 and RVF also this good medication for preparing combined vaccine of pneumo-3 and RVF

Preliminary trials for the improvement of the locally produced inactivated RVF vaccine

After the last outbreak of RVF in Egypt during 1993, research works were directed towards the development of a much higher immunogenic and more potent inactivated RVF vaccine. The present work reports on the production of a much safer, more economic and potent inactivated vaccine as well as increasing its shelf live validity. The vaccine was safe when tested in suckling mice and potent when tested in adult mice and sheep. It had an ED[50] of 0.0005/ml. Yet, this vaccine has to be tried on a large scale to judge upon its validity for field use and/or replacing the present classical inactivated one