RESUMO
A presente revisão aborda a questão das reações adversas gastrintestinais aos antiinflamatórios não-esteróides no âmbito da farmacoepidemiologia. Estas reações expressam como sintomas (dor epigástrica, náusea, entre outros), lesões (erosões e úlceras gastroduodenais) e complicações (hemorragia digestiva e perfurações), e são alvo de pesquisas farmacoepidemiológicas ao nível internacional, dada a extensa utilização dessa classe de medicamentos. No Brasil, a farmacoepidemiologia ainda constitui um campo de pesquisa científica em construção, fato que reforça a necessidade de se intensificarem os estudos nesta área, diante da complexidade que envolve a utilização de medicamentos no país.
Assuntos
Humanos , Anti-Inflamatórios não Esteroides , Sistema Digestório , Farmacoepidemiologia , Acetatos , Anti-Inflamatórios não Esteroides , Dipirona , Uso de Medicamentos , Fenoprofeno , Naproxeno , Piroxicam , SalicilatosRESUMO
The use of nonsteroidal antiinflammatory drugs (NSAIDs) can be complicated by severe forms of renal dysfunction. These include fluid and electrolyte abnormalities, acute renal insufficiency due to alteration in renal hemodynamics, or interstitial nephritis and proteinuria secondary to glomerular pathology, which has the histologic characteristics of minimal change glomerulopathy (MCG). While NSAID-induced nephrotic syndrome characteristically consists of MCG with interstitial nephritis, which is the most common clinical manifestation, it rarely consists of MCG without interstitial nephritis, which has been reported in a handful of patients who took fenoprofen, ibuprofen, sulindac, diclofenac, or zomepirac. We experienced a 66-year-old female patient who presented with low serum albumin, proteinuria and generalized edema and received Geworin for about 2 year before developing symptoms. She histologically had MCG without interstitial nephritis and achieved a complete remission thirty-fifth days after discontinuing the drug. A cause-and-effect relationship of this disease to Geworin administration is strongly suggested by the resolution of the proteinuria after the drug was stopped and by no evidence of any impairment in renal function after twenty eight months of follow-up.
Assuntos
Idoso , Feminino , Humanos , Injúria Renal Aguda , Analgésicos , Anti-Inflamatórios , Antipirina , Diclofenaco , Edema , Fenoprofeno , Seguimentos , Mãos , Hemodinâmica , Ibuprofeno , Nefrite , Nefrite Intersticial , Nefrose Lipoide , Síndrome Nefrótica , Patologia , Proteinúria , Albumina Sérica , SulindacoRESUMO
El presente trabajo tiene como objetivo describir las características farmacocinéticas, metabólicas y toxicológicas de los ácidos asimétricos aril-2-propiónicos y mostrar la importante variabilidad inter-especies existentes. Además se explican las derivaciones metabólicas del proceso de inversión quiral (camino metabólico de crucial importancia para estos compuestos) y las consecuencias toxicológicas relacionadas con su naturaleza quiral
Assuntos
Humanos , Propionatos/química , Anti-Inflamatórios não Esteroides/toxicidade , Fenoprofeno/toxicidade , Cetoprofeno/toxicidade , Conformação Molecular , Albumina Sérica , Fenoprofeno/metabolismo , Fenoprofeno/farmacologia , Cetoprofeno/metabolismo , Cetoprofeno/farmacologia , Oxigenases/farmacologia , Prostaglandinas/biossínteseRESUMO
The ulcerogenic effect of fenopron and its protection by paracetamol was observed under dissecting as well as laboratory microscope. The protection was complete under dissecting microscope, in the dose of 250 mg/kg. body weight but there was significant decrease in erosion score with gum acacia followed by fenopron. Mucosal thickness was significantly increased in paracetamol followed by fenopron group as compared to other group. Increased secretory activity of mucous neck cells was observed in the same group which might have resulted as protection of rat stomach by the damaging effect of fenopron; due to increased production of mucous as well as prostaglandin