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Indian J Exp Biol ; 2001 Dec; 39(12): 1302-4
Artigo em Inglês | IMSEAR | ID: sea-55625

RESUMO

Nine extracts of H. perforatum, containing hyperforin in conjugated forms, but devoid of free hyperforin and adhyperforin, were subjected to antidepressant screening using the forced swim test (FST). The observed activity was compared with that of SJW extracts containing hyperforin and adhyperforin (in free form). Results indicate that hyperforin conjugates exhibit significant antidepressant activity as evidenced by the reduced immobility period in the FST in rats.


Assuntos
Animais , Antidepressivos/isolamento & purificação , Compostos Bicíclicos com Pontes , Feminino , Hypericum/química , Masculino , Floroglucinol/análogos & derivados , Extratos Vegetais/farmacologia , Ratos , Natação , Terpenos/isolamento & purificação
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