1.
Rev. méd. Chile
;
136(6): 763-766, jun. 2008. ilus
Artigo
em Espanhol
| LILACS
| ID: lil-490763
RESUMO
Retinoic acid is a widely used drug in the treatment of cystic acné. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months of female whose mother was exposed to retinoic acid in both pregestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms ofthe teratogenic effeets of retinoic acid.