Scanning Electron Microscopic Study of the Eccrine Ostia of Mouse Foot Pads After Application of Antiperspirant

Recently, a topical preparation of 5% propantheline bromide and 10% aluminum hydroxychloride in an emulsion ground substance was introduced as an effective antiperspirant. According to the literature, aluminum salts may produce functional closure of swet ducts. Nevertheless, histologic study has as yet failed to reveal a solid anatomic basis for occlusion. In this study, the scanning electron microscope (SEM) was used to demonstrate eccrine gland ostial occlusion due to topical 5% propantheline bromide and 10% aluminum hydroxychloride.