RESUMO
Serum enzymes such as phosphohexoisomerase, aldolase and amylase were estimated in serum of 100 patients with thermal burn of different degrees. These enzymes were estimated at the time of admission, at 12th hour, 24th hour, 36th hour, 72nd hour, 7th day and 14th day. The patients with high serum levels of these enzymes till 72nd hour showed grave prognosis and serial measurements of these enzymes might help in predicting the outcome.
Assuntos
Adolescente , Adulto , Fatores Etários , Amilases/sangue , Superfície Corporal , Queimaduras/sangue , Estudos de Casos e Controles , Criança , Frutose-Bifosfato Aldolase/sangue , Glucose-6-Fosfato Isomerase/sangue , Humanos , Escala de Gravidade do Ferimento , Prognóstico , Estudos Prospectivos , Choque Cirúrgico/sangue , Taxa de Sobrevida , Fatores de TempoRESUMO
Ehrlich's test, serum mucoproproteins, phosphohexoisomerase (PHI), and lactate dehydrogenase (LDH) levels were studied in patients with cancer and age matched controls. All parameters studied were found to be significantly increased in cancer. Evaluation of Ehrlich's test, PHI and LDH for their validity as screening tests revealed that Ehrlich's test is better suited as a screening test for cancer. A positive correlation observed in the study between serum mucoproteins and Ehrlich's test strengthens the postulation that mucoproteins are responsible for the colour development in Ehrlich's test.
Assuntos
Glucose-6-Fosfato Isomerase/sangue , Humanos , Indicadores e Reagentes , L-Lactato Desidrogenase/sangue , Mucoproteínas/sangue , Neoplasias/sangue , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Biomarcadores Tumorais/sangueAssuntos
Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Antígeno Carcinoembrionário/análise , Neoplasias do Colo/diagnóstico , Glucose-6-Fosfato Isomerase/análise , Estadiamento de Neoplasias , Neoplasias Retais/diagnóstico , Sialoglicoproteínas/análise , Antígenos de Superfície/análise , Antígeno Carcinoembrionário/sangue , Glucose-6-Fosfato Isomerase/sangue , Neoplasias Hepáticas , Métodos , Metástase Neoplásica , Percloratos , Prognóstico , Estudos Prospectivos , UruguaiRESUMO
Serum levels of phosphohexose isomerase (PHI), aldolase (ALD) and hexokinase (HK) activities have been determined in 76 patients of carcinoma cervix, in search of proper diagnostic and prognostic parameters. All the three glycolytic enzyme levels studied were found to be significantly elevated in all the groups of malignancy and showed a relation to the clinical stage and tumor. Serum PHI levels were of best diagnostic significance even at an early stage of the disease. The enzyme levels correlated well with the prognosis of the disease.
Assuntos
Ensaios Enzimáticos Clínicos , Feminino , Frutose-Bifosfato Aldolase/sangue , Glucose-6-Fosfato Isomerase/sangue , Hexoquinase/sangue , Humanos , Prognóstico , Neoplasias do Colo do Útero/diagnósticoRESUMO
The serum phosphohexose isomerase (PHI), aldolase and hexokinase activities have been determined in 36 patients of carcinoma ovary with different clinical stages and in 25 healthy normal female subjects. The serum PHI and hexokinase levels were significantly elevated (P less than .001) in all the stages of malignancy while serum aldolase was significantly elevated only in stages III and IV of malignancy. The enzyme levels showed statistically significant response to therapy in stage II patients. The mean values in patients with progression of the disease were not significantly different.
Assuntos
Feminino , Frutose-Bifosfato Aldolase/sangue , Glucose-6-Fosfato Isomerase/sangue , Hexoquinase/sangue , Humanos , Estadiamento de Neoplasias , Neoplasias Ovarianas/enzimologiaRESUMO
The enzyme activities of Lactate dehydrogenase (LDH). prostate fluid LDH isoenzymes phosphohexose isomerase (PHI), Aldolase (ALD) and Hexokinase (HK) were determined in the sera of 77 samples of males. There were 12 cases of carcinoma prostate with metastases, 15 without metastases, 25 with benign prostatic hypertrophy and 25 nontumor. The enzyme activities of nontumor and benign group were statistically similar. The prostatic fluid LDH5/LDH1 ratio and PHI has been found to be the most sensitive parameter for detecting carcinoma prostate. Serial determinations of LDH, PHI, ALD and HK were found valuable for following the course of the disease during therapy.