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1.
Indian J Exp Biol ; 2006 May; 44(5): 399-402
Artigo em Inglês | IMSEAR | ID: sea-56950

RESUMO

Treatment of rats with paracetamol and CCl4 produced a significant increase in the levels of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total and direct bilirubin. Rats pretreated with methanolic extract of roots of H. indicus (100-500 mg/kg body weight, po) exhibited rise in the levels of these enzymes but it was significantly less as compared to those treated with paracetamol or CCl4 alone. The results of methanolic extract of H. indicus were comparable with the standard hepatoprotective agent silymarin (100 mg/kg). Maximum hepatoprotective effect was found to be at the dose of 250 mg/kg body weight in case of CCl4 induced hepatic damage while 500 mg/kg body weight in case of paracetamol induced hepatic damage. The results suggest that methanolic extract of H. indicus roots possesses a potential antihepatotoxic activity.


Assuntos
Acetaminofen/toxicidade , Animais , Tetracloreto de Carbono/toxicidade , Relação Dose-Resposta a Droga , Hemidesmus/química , Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle , Fígado/efeitos dos fármacos , Extratos Vegetais/farmacologia , Ratos , Ratos Wistar
2.
Indian J Exp Biol ; 2003 Apr; 41(4): 363-6
Artigo em Inglês | IMSEAR | ID: sea-59359

RESUMO

Methanolic extract of H. indicus root (MHI) was screened for its antimicrobial activity against S. typhimurium, E. coli and S. flexneri, in vitro and in experimentally induced diarrhoea in albino rats, in vivo. MHI had an anti enterobacteriae effect as evident from agar well diffusion method and decrease in CFU/ml in MHI treated LB broth culture. MHI inhibited the castor oil induced diarrhoea in rats as judged by a decrease in the amount of wet faeces in MHI-pretreated rats at a dose of 500-1500 mg/kg. The results indicated that MHI was more active than standard antidiarrhoeal drug, lomotil. Phytochemical tests revealed the main constituents as tannins, steroids, triterpenoids and carbohydrates. Present findings suggested that MHI might elicit an antidiarrhoeal effect by inhibition of intestinal motility and by its bacteriocidal activity.


Assuntos
Animais , Antibacterianos/uso terapêutico , Antidiarreicos/química , Bactérias/efeitos dos fármacos , Óleo de Rícino/toxicidade , Diarreia/induzido quimicamente , Fezes/química , Feminino , Hemidesmus/química , Masculino , Metanol/metabolismo , Testes de Sensibilidade Microbiana , Fitoterapia , Extratos Vegetais/química , Raízes de Plantas/química , Ratos , Ratos Wistar
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