study of the effect of magnesium hydroxide on the wound healing process in rats

Wound healing is the restoration of physical integrity to internal and external structures and involves intricate interactions between the cells and numerous other factors. Appropriate treatment and care are essential for acceleration of the healing process, prevention of infection and chronicity of the wound and different means and approaches have thus far been used to this end. The aim of this study was to evaluate the effect of magnesium hydroxide that was used for prevention of bed sores erstwhile on the wound healing process. The effect of magnesium hydroxide on the healing process in two models of skin wound; length wounds of 15 mm full-thickness and round wounds of 5 mm in diameter full thickness incision were created in the paravertebral area, 1.5 mm from midline on the back of rats was evaluated through measuring the length and area of the healed region and process pathological on different days, and conducting tensiometry experiments after complete wound healing. The percentage of wound healing on days 3, 6, 9, 12 and 15 in control group of length wounds changed in the group treated with magnesium hydroxide from 10.13%, 31.88%, 52.46%, 78.75% and 100% to 11.63%, 49.75% [p<0.05], 94% [p<0.01], 100% and 100% respectively; also the percentage of wound healing on days 3, 6, 9, 12, 15 and 18 in control group of round wounds changed in the group treated with magnesium hydroxide from 9.88%, 21.25%, 52.13%, 69.63%, 88.21% and 100% to 12.25%, 37.25% [p<0.05], 60.5%, 76%, 93.4% and 100% respectively. Stress [maximum tensile force causing skin rupture] changed from 13.19 Newton [N] in the control group of length wound to 20.87 N, also from 11.78 N [p<0.05] in the control group of round wound to 16.9 N [p<0.05] in group treated with magnesium hydroxide. Strain [tissue length under maximum strain] changed from 9.98mm in the control group of length wound to 15.43mm [p<0.05], also from 10.53 mm in the control group of round wound to 17mm [p<0.05] in group treated with magnesium hydroxide. The result of pathological samples of view histological [wound healing and cell aggregative] accelerated in magnesium groups on length and round wounds partition to control groups. Our findings suggest that magnesium hydroxide may have accelerated the skin wound healing process in rat and increased tissue strength through stimulating collagen formation

Antiulcer activity and the mechanism of action of magaldrate in gastric ulceration models of rat.

The present study was undertaken to investigate the mechanism of cytoprotective effects of magaldrate in aspirin plus pylorus-ligation model and ethanol-induced gastric ulcer model in rats. Magaldrate (60 mg/kg, p.o.) produced a significant reduction in the ulcer index and significant increase in mucus content in ethanol-induced gastric ulceration in rats. In aspirin plus pylorus-ligation model magaldrate produced significant decrease in ulcer index, total acidity and protein content (PR). It did not produce any significant change in volume of gastric secretion. However, it produced significant increase in total carbohydrate (TC) level but not in ratio between TC and proteins. It also produced a significant decrease in lipid peroxidation (as expressed by thiobarbituric acid reactive substance). Our data suggests the cytoprotective action of magaldrate on gastric mucosal cells which may be due to protection of gastric mucosa from lipid peroxidation.

Evaluación in vivo del efecto de los antiácidos y bloqueadores H2 sobre el pH intragástrico en la úlcera gástrica y duodenal / In vivo evaluation of the effect of antacids and H2 receptor blockaders on the intragastric pH in gastric and duodenal ulcer

El objetivo del presente estudio, fue evaluar "in vivo" la acción de los antiácidos y de los antagonistas de los receptores H2, sobre el pH gástrico, en pacientes portadores de ulceras gástricas y duodenales, con el fin de establecer cual es la medicación más efectiva. Se estudiaron 16 pacientes ulcerosos: nueve eran portadores de Ulcera Duodenal, dos tenían Ulcera Gástrica y cinco presentaban Ulcera Gástrica y Duodenal. En cada paciente se obtuvo el contenido gástrico por aspiración mediante una sonda nasogástrica, en forma horaria desde la hora 8 a la hora 20; midiéndose la secreción nocturna por aspiración a la hora 8 del día siguiente, estando el paciente en ayunas y sin medicación. El mismo procedimiento se repitó en cada paciente administrando Cimetidina (a la dosis de 1 g. por día), Ranitidina (a la dosis de 300 mg. por día), Hidróxido de Aluminio y Magnesio (a la dosis de 150 ml por día) y finalmente se repitió el procedimiento asociando la Ranitidina con el Hidróxido de Aluminio y Magnesio en las dosis anteriormente mencionadas. Se realizó un análisis estadístico de los resultados, calculándose la ordenada media de pH. El efecto medio del tratamiento se obtuvo promediando las diferencias individuales (pH tratamiento - pH sin tratamiento). El mismo procedimiento se empleó para la comparación de los diferentes fármacos entre sí. Se realizaron pruebas de Student para muestras dependientes con un nivel de significación de alfa = 5%. La capacidad de neutralización se midió por la proporción del total de muestras con un pH igual o mayor a 4, obtenidos en cada tratamiento y en el total de pacientes, comparándose con los resultados hallados sin medicación. Se utilizó el x2 con corrección de Yates. Todas las medicaciones fueron eficaces (aunque en diferente grado) para neutralizar la acidez gástrica. La combinación del antiácido con la Ranitidina apareció como lo más eficaz, mostrando diferencias estadísticamente significativas con la Cimetidina y el Hidróxido de Aluminio, y Magnesio, no así con la Ranitidina sola