Spectrophotometric determination of amoxicillin and cefadroxil using 3-methyl-2bencothiazolone hydrazone hydrochloride

A spectrophotometric method was described for the determination of amoxycillin and cefadroxil. The method was based on the reaction of these drugs with 3-methyl-2-benzothiazolone hydrazone hydrochloride [MBTH] in the presence of cerric ammonium sulfate. The colored products were estimated spectrophotometrically at 530 nm and 511 nm for amoxycillin and cefadroxil, respectively. Beer's Law was valid over the concentration range 10-50 mug ml -1. The method was applied successfully to the analysis of dosage forms. Relative st and ard deviations for the assay of both drugs in commercial preparations were less than 1%