Clinical study of the Ginko biloba--Troxerutin-Heptaminol Hce in the treatment of acute hemorrhoidal attacks.

OBJECTIVE: The aim of this study was to assess the clinical efficacy, compliance and safety of Ginko biloba--Troxerutin-Heptaminol Hce in the treatment of patients with acute hemorrhoidal attacks in Thailand. MATERIAL AND METHOD: In a prospective clinical study on hospital outpatients, the authors studied the effect of Ginko biloba--Troxerutin-Heptaminol Hce for a week in adults (18-70 years old) with acute hemorrhoidal attacks. RESULT: Twenty-two patients, with a mean age of 41.7 years were included in the study. The male to female ratio was 1 : 1.2. Most patients (77%) had grade 1 and 2 hemorrhoids with an average duration of attacks of 3 days. On intention to treat analysis, bleeding, pain, tenesmus and discharge were significantly improved. Treatment was well accepted and safe. CONCLUSION: In the short-term, Ginko biloba--Troxerutin-Heptaminol Hce is effective, acceptable and safe in the treatment of patients with acute hemorrhoidal attacks.

Aphakic and pseudophakic cystoid macular edema

To evaluate the effectiveness of medical treatment in patients with aphakic and pseudophakic cystoid macular edema [CME]. A two years prospective study of 25 cases with CME following cataract surgery. Every case underwent full ophthalmological examination and fluorescein fundus angiography. All cases treated by topical non-steroidal anti-inflammatory [Diclofenac 01%] ophthalmic solution 1-2 drops 4 times a day, 10 cases received 0 - [B - hydroxyaethyl] -rutosidea [Venoruton - 300] capsules 1200 mg in two divided oral dose daily for 2 weeks together with the topical diclofenac. Follow-up ranged 6 - 30 months [mean 19 months]. The 25 eyes of 25 patients all unilateral. 21[84.0%] pseudophakic and 4[16.0%] aphakic. Mean duration of CME [10.50 months]. Mean BCVA 0.2. Two groups were identified according to medical treatment, Group A - 15 cases received diclofenac 0.1% alone with 13 [86.7%] improved in a mean period of 8.5 weeks, 2 [13.4%] not improved and 3 [23.1%] with on/off phenomenon. Group B - 10 cases received topical diclofenac 0.1% together with Venoruton 300 capsules 9 [90.0%] improved in a mean 5 weeks, 1 [10.0%] not improved and 1 [11.2%] with on/off phenomenon. Topical non - steroidal anti-inflammatory drugs [Diclofenic 0.1%] ophthalmic solution proved to be beneficial in the prevention and treatment of chronic aphakic and pseudopahkic cystoid macular edema. Oral O - [B - hydroxyaethyl] - rutosidea [Venoruton 300] capsules was beneficial in the present study in augmenting the action of topical diclofenac by shortening the duration of recovery and lowering the rate of recurrence [on/off] phenomenon, but needs further studies