Síndrome de quilomicronemia: aspectos genéticos y revisión de la literatura / Chylomicronemia syndrome: genetic aspects and literature review

Chylomicronemia syndrome is a metabolic condition characterized by severe hypertriglyceridemia and fasting chylomicronemia, secondary to an alteration in the ability to metabolize triglycerides. It can respond to different etiologies, the most frequent being multifactorial. Familial chylomicronemia syndrome, on the other hand, represents an infrequent cause of chylomicronemia syndrome, showing an autosomal recessive inheritance pattern. It's caused by pathogenic variants in genes related to chylomicron's metabolism, mainly LPL1 gene. One of the main associated risks is the occurrence of acute pancreatitis, which can also have a recurrent course. The primary therapy goal in patients with this condition is prevention of pancreatitis and related comorbidities. The treatment basis consists in reduce chylomicron formation by restriction of dietary fat, in association with physical activity and pharmacologic therapy. It is important to distinguish the etiology of chylomicronemia syndrome since it has repercussions in terms of response to treatment, complications, and recurrence risk. (AU)

[Effect of 8-week walking program on serum lipoprotein [a] concentration in non-athlete menopausal women]

Lipoprotein [a] [Lp[a]] is a new cardiovascular risk factor and its concentration increase cardiovascular diseases, while physical activity decrease cardiovascular diseases. This study intend to investigate the effect of eight week walking program on lipoprotein [a] concentration in non-athlete Iranian menopausal women. Twenty two healthy menopause women of 47-55 year of age any specific disorder were enrolled in this study. The subjects randomly divided into experimental and control groups. Anthropometric characteristics including height, weight, body mass index [BMI], body fat percent and Waist-to-Hip ratio [WHR] and serum lipoprotein on fasting were measured pre and post-walking program. The data were compared using independent t-test, U mann witny and pearson correlation coefficient was used for assessement of relation between lipoprotein [a] with anthropometric indexes. According to these results, there was a significant reduction of serum lipoprotein [a] [pre test12.5 +/- 4/1; post test 10.5 +/- 3md], WHR, BMI and body fat percent prior and after the training in experimental group [P<0.05] while non significant changes was observed in control group. Also, there was non significant relationship between lipoprotein [a] with Anthropometric indexes. This study revealed that 8-week walking program had useful effects on menopausal women' serum lipoprotein [a] concentration, WHR, BMI and body fat percent

effect of co-administration of aquous extract of bunium persicum and endurance training on plasma lipids in hypercholesterolemic male mice

The effect of endurance training on lipid profile and cardiovascular endurance in normal rat after Bunium Persicum Extract [BPE] administration has been previously investigated. In the present study, the effect of co-administration of endurance training and persicum extract on plasma lipid and lipoproteins in hypercholesterolemic male mice was examined. In this experimental study, 60 male mice were, randomly, divided into 4 groups: Vehicle, Endurance Training [ET], Bunium Persicum Extract Administer [BPEA] and ET-BPEA group. The Exercise protocol was performed at a speed of 18 m/min, 40 min/day, 5 day/week for 6-weeks. The Bunium Persicum Extract was also administered in the same period and the desired dose [0.8 mg] was reconstituted in 0.4 ml of distilled water. The amount of Triglyceride [TG], Total Cholesterol [TC], HDL-c, LDL-c and Body Weight were registered at the beginning and also at the end of the 6 weeks. Data were analysed using one-way ANOVA method. The results indicated that the 6-week endurance training accompanied by Bunium Persicum aquous extract administration reduced TC [pretest; 297.7 +/- 37.08, post test; 146.1 +/- 30.8, p=0.019] and LDL-c concentrations [pretest; 151.8 +/- 14.4, post test; 0.12 +/- 8.7, p=0.00l]. On the other hand, Bunium Persicum aquous extract administration increased HDL-c concentration significantly [pretest; 75.9 +/- 12.1, post test; 119.9 +/- 17.9, p=0.003]. Furthermore, the results showed that body weight changes were not significant. These results suggest that co-administration of BPE and ET could significantly affect plasma lipid and lipoproteins. Therfore performing such program maybe useful for preventing cardiovascular diseases

Gemfibrozil en el manejo de las dislipidemias / Genfibrozil in the management of hyperlipidemia

Propósito: evaluar la eficacia del Gemfibrozil en pacientes con Dislipidemias. Material y Métodos: Se estudiaron un total de 30 pacientes que consultaron la Emergencia de Adultos del Hospital Central de Valencia y el Centro Médico Lara, durante el lapso de tiempo comprendido entre enero a septiembre de 1992 por presentar dislipidemias

Hiperlipoproteinemias / Hyperlipoproteinemias

Os autores revisam o metabolismo das lipoproteínas plasmáticas e a fisiopatologia das hiperlipoproteínas primárias e secundárias. Säo descritos o quadro clínico e o manejo terapêutico de cada classe clínica