RESUMO
Genes play an important role in the immune system response, and different gene loci may result in different vaccine immune response rates. This review focuses on the correlation between gene polymorphisms and vaccine immune response in order to investigate the influence of gene polymorphisms on the immune response to vaccines. It discusses the effect of an individual's immune response after vaccination at genetic level and provides a scientific basis for individualized immune development strategies. It reveals that human leukocyte antigen genes, various cytokines and their receptor genes, and Toll-like receptor genes all affect the vaccine immune response.
Assuntos
Humanos , Citocinas , Variação Genética/imunologia , Sistema Imunitário , Imunidade/fisiologia , Imunidade Ativa/imunologia , Imunogenética , Polimorfismo Genético , Vacinação , Vacinas/imunologiaAssuntos
Adolescente , Anticorpos Antivirais/sangue , Criança , Pré-Escolar , Feminino , Humanos , Imunidade Ativa/imunologia , Imunização , Programas de Imunização , Irã (Geográfico) , Masculino , Sarampo/imunologia , Vacina contra Sarampo/administração & dosagem , Vírus do Sarampo/efeitos dos fármacos , Vigilância da PopulaçãoRESUMO
To determine the prevalence of rubella antibodies and age of exposure to rubella among Yemeni schoolgirls, we studied the sera samples of 323 female students [age range 11-21 years; mean age 16.26 +/- 1.89 years] drawn from three schools in Sana'a. All samples were screened for rubella IgG antibodies using enzyme linked immunosorbent assay and, if negative, for IgM in order to exclude the possibility of recent exposure. Of 323 sera, 296 [91.64%] were positive for rubella IgG. All IgG negative sera were also IgM negative. Comparable antibody prevalence was observed in all age groups. The prevalence of rubella IgG among Yemeni schoolgirls is high, with most becoming immune between the ages of 11 and 21 years. Although the age of exposure seems to be