Study of urinary immunoglobulins [IgG, IgM and IgAs] in children with urinary tract infections

Urinary immunoglobulins [IgG, IgAs and IgM] were studied in 30 children with urinary tract infection to detect the possibility of a defect in the local immune response among these children. The study showed that their urinary IgAs and IgG were significantly higher than in normal age mactched children, indicating that children with urinary tract infection react by increasing locally produced immunoglobulins in urine. Children with recurrent attacks showed lower level of IgG in urine which may denote a partial impairment in the local immune response. Urinary immunoglobulins were not found to vary significantly according to age, sex or symptomatology