RESUMO
Os autores fazem uma revisão bibliográfica atualizada sobre a etiologia, manifestações clínicas, diagnóstico, tratamento, prognóstico e prevenção da doença meningocócica
Assuntos
Humanos , Masculino , Feminino , Infecções Meningocócicas/diagnóstico , Infecções Meningocócicas/epidemiologia , Infecções Meningocócicas/etiologia , Infecções Meningocócicas/fisiopatologia , Infecções Meningocócicas/patologia , Infecções Meningocócicas/prevenção & controle , Infecções Meningocócicas/terapia , Meningite Meningocócica , Neisseria meningitidisRESUMO
This study was performed to determine the incidence and serogroups of meningococcal disease in the Korean Army. From August 2000 to July 2001, we identified prospective cases in the Korean Army. Meningococcal disease was confirmed by isolation of Neisseria meningitidis or detection of its antigen by latex agglutination from cerebrospinal fluid (CSF) or blood. Polymerase chain reactions (PCRs) were performed in the crgA gene to identify N. meningitidis regardless of its serogroup, and then in orf-2 (serogroup A) and siaD (serogroups B, C, Y, and W135) respectively for serogroup prediction. During the study period, twelve patients (four meningitis and eight septicaemia) were identified. The annual incidence was 2.2 per 100,000 (95% confidence interval, 1.3-3.8) among 550,000 private soldiers. Latex agglutinations were positive to A/C/Y/W135 polyvalent latex, but not to B latex in all patients. PCRs of crgA gene were positive in ten patients, whose samples (2 isolates from CSF, 2 CSFs, and 6 sera) were stored. In PCRs for serogroup prediction, one isolate was serogroup A, and one isolate and two sera were serogroup C. The need for meningococcal vaccination would be considered in the Korean Army through the cost-benefit analysis based on the result of this study.
Assuntos
Adulto , Humanos , Masculino , Coreia (Geográfico)/epidemiologia , Infecções Meningocócicas/epidemiologia , Infecções Meningocócicas/fisiopatologia , Militares , Neisseria meningitidis/genética , SorotipagemRESUMO
No presente trabalho realiza-se uma analise de varios fatores implicados no prognostico da doenca meningococica, numa populacao infantil. Foram estudados 152 casos de Doenca Meningococica no Hospital Infantil Joana de Gusmao, no periodo de janeiro de 1980 a marco de 1989. Analisaram-se os seguintes fatores prognosticos: duracao do quadro clinico, coagulacao vascular disseminada, choque, convulsao, estado de consciencia, lesoes da pele, hipoglicorraquia e leucopenia.