RESUMO
Abstract Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.
Assuntos
Animais , Masculino , Ratos , Peritonite/tratamento farmacológico , Infecções por Bacteroides/complicações , Envelhecimento , Antibacterianos/uso terapêutico , Peritonite/microbiologia , Ratos Wistar , Sepse/tratamento farmacológico , Modelos Animais de Doenças , FezesRESUMO
Se present ael caso de una paciente de 50 años que durante la internación por un severo cuadro de artritis reumatoidea, desarrolló una bacteriemia por Bacteroides distasonis a partir de una colecistitis no reconocida y cuya expresión final fue una meningitis. La evolución de la paciente no fue favorable por no haber recibido la terapia antibiótica adecuada en forma temprana. El diagnóstico etiológico fue realizado a través del estudio microbiológico del líquido cefalorraquídeo transportado y cultivado en aero y anaerobiosis. Este procedimiento es importante en aquellos pacientes que presentan procesos infecciosos agudos o crónicos pulmonares, intraabdominales o craneofaciales y que además son inmunocomprometidos. En tales casos debe incorporarse al esquema terapéutico inicial un antibiótico efectivo en el tratamiento de los gérmenes anaerobios que pudieran estar involucrados