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Indian J Exp Biol ; 1989 Dec; 27(12): 1067-70
Artigo em Inglês | IMSEAR | ID: sea-63295

RESUMO

Status of xanthine oxidase, superoxide dismutase, catalase and lipid peroxidation, the enzymes metabolizing reactive oxygen intermediates in liver, lungs and spleen of M. natalensis during D. viteae infection was investigated. Xanthine oxidase and lipid peroxidation exhibited stimulation, while superoxide dismutase and catalase showed depression in liver and spleen of the infected animals. The filarial infection therefore appears to create O2 toxicity in these tissues. Lungs, on the other hand was found safe as it possessed elevated xanthine oxidase, superoxide dismutase and catalase. Lipid peroxidation in lungs operated below the control level. The impact of these changes in the establishment and development of the infection has been discussed.


Assuntos
Análise de Variância , Animais , Catalase/biossíntese , Infecções por Dipetalonema/metabolismo , Filariose/metabolismo , Peroxidação de Lipídeos , Muridae , Superóxido Dismutase/biossíntese , Xantina Oxidase/biossíntese
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