Experimental injury to the spleen study of interaction: contamination preservation

A ablacao do baco acarreta aumento consideravel do risco de aparecimento de infeccoes invasivas pos-esplenectomia. Esse conceito ganhou grande dimensao nas ultimas tres decadas, apos correto conhecimento das importantes funcoes imunologicas desempenhadas pelo baco. Tais fatos tem conduzido inumeros centros de pesquisa na busca de hemostasia da viscera lesada, objetivando-se a manutencao da funcao do orgao. O escopo deste trabalho e analisar aspectos da conservacao do baco traumatizado, com o auxilio de malha de nylon, na presenca ou nao de contaminacao local. Foram operados 20 caes, divididos aleatoriamente em 02 grupos iguais e seguidos por periodo pos-operatorio de 08 semanas...

Antibiotic associated colitis.

It is a prospective study based on 100 consecutive cases of diarrhea following antibiotic therapy admitted to the pediatric services of J.N. Medical College, A.M.U., Aligarh between January to December 1987. They had C. penicillin (50), chloramphenicol (34), ampicillin (34), gentamicin (34), cephalosporin (4) and cotrimoxazole (4) for 3 days to 3 weeks prior to the onset of diarrhea. Apart from routine and special investigations, naked eye and microscopic examination of stool, its culture for pathogens including Cl. difficile were carried out in all cases. Presence of Cl. difficile cytotoxin was demonstrated by observing the cytopathic. Effect on veru cell culture, 18 grew Cl. difficile (14 cyto toxin positive). Frequency of fever, vomiting, abdominal distension, dehydration and duration of diarrhea was not different (p > 0.05) in the two groups. Purge rate and presence of mucus and blood in Cl. difficile positive patients was significantly higher (p < 0.05). Eight Cl. difficile positive (7 cytotoxin+ve) were subjected to endoscopy. Three of them showed P.M. colitis and 2 non specific colitis. Chloromycetin, gentamicin and penicillin were the main culprits responsible for AAC. None of the patients given ampicillin alone suffered from AAC. The mortality was 5%.