study on the possible influence of meloxicam on the pharmacokinetic of a certain narrow therapeutic index drug in rabbits

The present work aimed at evaluating the possible effect of meloxicam on bioavailability and pharmacokinetic of single and repetitive dose of theophylline. The study was conducted on male rabbits. Drugs were administered orally. Theophylline administered as single dose [regimen I] or in concomitant administration with meloxicam following 7 days of meloxicam administration [regimen II]. Multiple dose study was conducted in three groups. The first one for meloxicam, the second for theophylline and the last for their co-administration. Assay of theophylline as well as meloxicam was performed by high performance liquid chromatography. The pharmacokinetic analysis was performed using the non-compartmental analysis. No significant differences between two regimens were found with respect to the main pharmacokinetic parameters of single dose as well as on steady state pharmacokinetic of theophylline according to the bioequivalence guidelines. However, study of within individual variability for Cmax and AUC0-inf revealed that there was a wide variation between individuals with respect to the effect of meloxicam on theophylline pharmacokinetics. The clinical significant of this work should be stressed on theophylline plasma concentration to be monitored in patients receiving concomitant meloxicam and theophylline therapy

Evaluation of the analgesic and anti-inflammatory effects of Harpagophytum procumbens in albino rats: a comparative study with indomethacin and rofecoxib

Harpagophytum procumbens [Harpago.] is a herpaceous plant. It has been used in traditional medicine for treatment of many diseases including headache, rheumatic diseases and inflammations. The aim of the present study is to evaluate the analgesic and anti-inflammatory effects of the herpal plant on the experimentally-induced acute inflammation [carrageenan-induced edema test] and chronic inflammation [Freund's adjuvant-induced arthritis] in adult male albino rats. In addition, these actions were compared with that of indomethacin and rofecoxib. The results of the present work revealed that Harpago. aqueous extract and indomethacin, completely, prevented the carrageenan-induced paw edema. Also, they significantly increased the paw withdrawal latency [reaction time] that reflects the analgesic effect of the drugs. The intensity of the latter effects reached maximum level when measured after 1-2 hours for both drugs. Meanwhile, rofecoxib produced significant reduction in the paw edema that induced by carrageenan and elicited an analgesic effect that reached maximum level after 3-4 hours from carragednan injection. Concerning the chronic anti-inflammatory effects, Harpago-protected the knee joint from the Freund's adjuvant-induced degenerative changes, however, this protection is much less than that produced by each of indomethacin or rofecoxib. Thus, it could be concluded that Harpagophytum procumbens has analgesic and anti-inflammatory effect in the acute and chronic inflammatory conditions which is more prominent in the acute and subacute inflammations; and its duration of action is similar to indomethacin, but shorter than that of rofecoxib

Anti cox II for analgesia and bleeding after day-case adenotonsillectomy

Adenotonsillectomy is performed as a day surgery. We have examined the analgesic utility and incidence of bleeding after intramuscular injection of Anti Cox II, Ketorolac and Pethidine which were given after induction of anaesthesia. Although the analgesic effects of three drugs were comparable in the immediate post operative peroid.The recovery time taken to awake and ambulate for discharge were significantly shorter after Ketorolac and Anti Cox II. Anti Cox II is prefered than Ketorolac due to reduced risk of gastritis and bleeding