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1.
Braz. J. Pharm. Sci. (Online) ; 54(2): e00246, 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-951938

RESUMO

ABSTRACT The purpose of this work was to evaluate the influence of the clinical profile on lamotrigine (LTG) plasma concentrations from patients with refractory epileptic seizures. In this cross-sectional study, therapeutic monitoring of LTG, and questionnaires with 75 patients with refractory epileptic seizures of a Hospital in Ribeirão Preto-SP-Brazil were performed. The multiple linear regression model was used to verify association between the LTG plasma concentrations and the independent variables. Covariance analysis was used to compare the mean LTG plasma concentration among the co-medication groups. The LTG plasma concentration was associated both with the LTG dosage (mg/kg/day) (p=0.0096) and with the use of first generation antiepileptic drugs (AED) (p<0.01), being carbamazepine (CBZ) and phenytoin (PHT), the AEDs showing the most prominent influence in reducing LTG plasma concentrations. Adverse events, adherence to the pharmacological treatment, and epileptic seizures frequency, did not show significant correlation with LTG plasma concentration values. The conclusion is that LTG plasma concentration is significantly influenced by the LTG dosage and by the concomitant use of a first generation AED.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Interações Medicamentosas/imunologia , Anticonvulsivantes/análise , Tratamento Farmacológico/estatística & dados numéricos , Epilepsia Resistente a Medicamentos/tratamento farmacológico
2.
Artigo em Espanhol | LILACS | ID: lil-265830

RESUMO

Se hace una revisión de los antifúngicos disponibles en el mercado internacional en la actualidad, se profundiza más en el anfotericín B, con sus virtudes y reacciones adversas, así como de otros antifúngicos, sobre todo los derivados azoles, imidazólicos y los triazoles, como compuestos con buenos resultados y menos reacciones secundarias, en particular el fluconazol y el itraconazol y sus características


Assuntos
Anfotericina B/administração & dosagem , Anfotericina B/efeitos adversos , Anfotericina B/uso terapêutico , Interações Medicamentosas/imunologia , Flucitosina/administração & dosagem , Flucitosina/efeitos adversos , Flucitosina/uso terapêutico , Cetoconazol/efeitos adversos , Cetoconazol/uso terapêutico , Micoses/tratamento farmacológico , Itraconazol/administração & dosagem , Itraconazol/efeitos adversos , Itraconazol/uso terapêutico
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