[Effect of exercise program and curcumin supplementation on serum level of immunoglobulin A in rats exposed to lead acetate]

Lead as an environmental pollutant can damage the immune system. This study was done to determine the effect of moderate-intensity exercise and Curcumin supplement on serum level of immunoglobulin A in rats exposed to lead acetate. In this experimental study, 46 male rats were allocated into six groups including; Control [C], vehicle [V], lead [L], lead and exercise [LE], lead and curcumin [LC], Lead+exercise+curcumin [LEC]. Animals in training groups ran on treadmill for 8 weeks [25- 64 minutes per daily, 15-22 meter/minute and 0% grade]. Animals in Lead, LE, LC and LEC groups were received lead acetate [20 mg/kg/bw] and vehicle animals were received ethyl oleat [30 mg/kg/bw] Intraperitoneally for 3 days per week for 8 weeks. Rats in curcumin and LEC groups were received Curcumin [30mg/kg/bw], for 3 day per week for 8 weeks. IgA level were measured by single radial immuno diffusion method. Lead acetate significantly increased MDA levels at P<0.05 in animals. IgA level was 0.2, 0.41 and 0.47 mg/dL in Lead, LE and LEC groups [P<0.05]. The simultaneous use of endurance exercise training and curcumin due to increased IgA activity has beneficial effects against lead poisoning

Possível intermediaçäo do sistema imune na polineuropatia periférica plúmbica: relato de caso / Possible role of the immune system in lead neuropathy: case report

Relata-se o caso de paciente de 25 anos com ferimento porarma de fogo na articulacao coxofemural esquerda que desenvolveu, entre outros sinais de intoxicacao plumbica, polineuropatia periferica axonal predominantemente motora. Tratado inicialmente com corticosteroides em doses imunossupressoras obteve melhora, mas apresentava recidiva a cada tentativa de retirada da medicacao. Demonstrados laboratorialmente niveis sericos toxicos de chumbo, foi submetido a quelacao com EDTA e a retirada cirurgica do projetil, com boa recuperacao dapolineuropatia, sem necessidade ulterior de corticosteroides. Enfatiza-se: 1) o possivel papel do sistema imune na fisiopatogenia da intoxicacao por chumbo, podendo ser um dos motivos das diferentes apresentacoes clinicas das neuropatias plumbicas na infancia e no adulto; 2) a importancia da retirada do material plumbeo quando alojado em articulacoes.