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Indian J Exp Biol ; 1989 Dec; 27(12): 1087-9
Artigo em Inglês | IMSEAR | ID: sea-56522

RESUMO

Effect of oral administration of gossypol acetic acid (15 mg/kg/day) for 10 weeks, on certain enzymes, which may be taken as markers for the different stages of spermatogenesis, was studied in male albino rats. Gossypol produced a significant decrease in hyaluronidase and sorbitol dehydrogenase, while no change was observed in beta-glucuronidase and acid phosphatase. A significant increase in the total lactate dehydrogenase activity was observed in the testis. The possible significance of these findings is discussed.


Assuntos
Animais , Glucuronidase/metabolismo , Gossipol/farmacologia , Hialuronoglucosaminidase/metabolismo , L-Iditol 2-Desidrogenase/metabolismo , L-Lactato Desidrogenase/metabolismo , Masculino , Ratos , Ratos Endogâmicos , Espermatogênese/efeitos dos fármacos , Testículo/efeitos dos fármacos
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