Leiomiomatosis peritoneal diseminada en paciente histerectomizada / Disseminated Peritoneal Leiomyomatosis in a Hysterectomized Patient

La leiomiomatosis peritoneal diseminada es una entidad rara de etiología incierta, caracterizada por la proliferación de múltiples nódulos benignos en la cavidad peritoneal, formados por células musculares lisas, que pueden simular una carcinomatosis peritoneal. Es más frecuente en mujeres en edad fértil, durante el embarazo o por el uso de anticonceptivos orales. Se presenta el caso de una mujer de 40 años diagnosticada de leiomiomatosis peritoneal diseminada, sometida a una histerectomía simple por miomatosis uterina. Después de dos años del diagnóstico presenta una exacerbación de la enfermedad y se sospecha de malignización, por lo que se realiza una laparotomía exploratoria donde se observan múltiples nódulos miomatosos extendidos por epiplón, peritoneo y apéndice. Se le practica la exéresis de todos los nódulos (omentectomía, apendicectomía y anexectomía bilateral(. La biopsia confirma el diagnóstico de leiomiomatosis peritoneal diseminada. Actualmente, la paciente permanece asintomática tras 6 años de seguimiento(AU)

Disseminated peritoneal leiomyomatosis is a rare entity of uncertain etiology, characterized by the proliferation of multiple benign nodules in the peritoneal cavity. These nodules are formed by smooth muscle cells, which can simulate peritoneal carcinomatosis. It manifests predominantly in women of childbearing age, especially during pregnancy or with the use of oral contraceptives. We report here the case of a 40-year-old woman diagnosed with disseminated peritoneal leiomyomatosis, who underwent simple hysterectomy due to uterine myomatosis. Two years after the diagnosis, she presented with an exacerbation of the disease and malignancy was suspected. So exploratory laparotomy was performed. Multiple myomatous nodules were observed, extended by omentum, peritoneum and appendix. All nodules were removed -omentectomy, appendectomy and bilateral adnexectomy. Biopsy confirms the diagnosis of disseminated peritoneal leiomyomatosis. As of today, the patient remains asymptomatic after 6 years of follow-up(AU)

Leiomiomatosis intravenosa de origen pelviano con extensión intracardiaca: Reporte de dos casos / Pelvic intravenous leiomyomatosis with intracardiac extension: Report of two cases

Background: symptoms predominate. Diagnosis is based on clinical findings and appropriate imaging. We report two females, aged 35 and 51 years. One of them presented with a pelvic mass and dyspnea, the other patient had severe cardiac failure on admission. Computed axial tomography scan allowed an accurate preoperative diagnosis on both patients. Successful one stage resection of the tumor was performed under cardiopulmonary bypass. Both patients are asymptomatic on follow up at 6 months and 25 years.

Intracardiac leiomyomatosis: Report of two cases.

Intravenous leiomyomatosis is an example of unusual growth patterns that is sometimes exhibited by uterine leiomyomas, characterized by smooth muscle proliferations within the uterine or pelvic veins. Extension into the heart via the inferior vena cava is even rarer and is designated as intracardiac leiomyomatosis. This is a report of two such cases that had preoperative diagnoses of a thrombus and right atrial myxoma, respectively.

Leiomiomatose peritoneal disseminada: relato de caso / Leiomyomatosis peritonealis disseminata: a case report

Neste trabalho relata-se o caso de uma paciente de 46 anos de idade com queixa de aumento de volume periumbilical e dor leve antes da menstruação. O quadro evoluiu com aumento gradativo da dor. Foram realizados ultra-som, tomografia computadorizada e ressonância magnética. Após laparotomia exploradora, foi retirado material para biópsia que confirmou o diagnóstico de leiomiomatose peritoneal disseminada.

The present study reports the case of a 46-year-old female patient complaining of mild premenstrual pain and increase in the volume of the periumbilical region. The condition progressed with a gradual increase of the pain intensity. Ultrasonography, computed tomography and magnetic resonance imaging were performed. Biopsy of tissue collected during exploratory laparotomy confirmed the diagnosis of leiomyomatosis peritonealis disseminata.

CD10 in diffuse uterine leiomyomatosis: a case report along with a few comments on histogenesis.

Diffuse uterine leiomyomatosis (DUL) is a rare entity with an unknown etiopathogenesis. A 24 years old female presented with abdominal discomfort and menorrhagia. Clinical and ultrasonographic examination revealed an enlarged uterus. The hysterectomy specimen showed a symmetrically enlarged uterus with a bosselated external surface. The cut surface showed multiple nodules of varying sizes diffusely involving the myometrium. Microscopically, the nodules were leiomyomas of varying degrees of cellularity. Some of the leiomyomas showed an increased vascularity either in the form of congeries of blood vessels with a lobular arrangement or occasionally as foci of 2-3 vessels. The vessels were surrounded by whorls of spindle cells. On immunohistochemistry the leiomyomas expressed vimentin, smooth muscle actin (SMA), desmin and CD10: the cells whorling around the blood vessels expressed vimentin, SMA and focally desmin and were negative for CD10 and HMB-45. The aim of this paper is to document that CD10 is expressed in diffuse uterine leiomyomatosis and discuss the histogenesis of DUL.

Premiere description de leiomyomatose peritoneale disseminee a Madagascar

"Leiomyomatosis peritonealis disseminata : first description of a case in Madagascar"" : The authors reported the first case of leiomyomatosis peritonealis disseminata or diffuse peritonealis leiomyomatosis in a patient of 36 years old. The hyalin degeneration of leiomyomatosis with intra and extra peritonealis extension is an uncommon pathology. Theright etiology of this complication of leiomyomatosis is unknown. Its detection is a fortuitous event during laparotomy. It is characterized by an extension to the serosa; a break-in of the tissues and unpredictable invasion of the contiguous organs; and it can touch the heart. Despite its rapid evolution; often accompanied by mechanical complications; it remains a benign tumour."

Leiomyoma of the kidney--report of two cases.

Renal leimyoma is an uncommon benign tumour, which pose a challenging diagnostic and therapeutic problem. When multiple (leiomyomatosis) they are preoperatively mistaken for malignant tumors. We herein-present one case of renal leiomyomatois developing in a 50 year old male, which was clinically diagnosed as renal cell carcinoma and one case of renal leiomyoma in a 37 year old male.

Leiomiomas del músculo piloerector / The pilar muscle leiomyoma

El leiomioma del músculo piloerector es un tumor benigno poco frecuente, que se presenta en adultos jóvenes. Puede ser solitario o formar agrupaciones de lesiones como el caso que se reporta en este trabajo. Pueden ser asintomáticos pero generalmente el paciente refiere dolor al tacto o espontáneo por lo que consulta. No se ha descrito la malignización de este tipo de tumor. El diagnóstico se realiza por análisis histológico el cual es característico. En este artículo se presenta el caso de un paciente de 28 años con lesiones nodulares firmes de color eritenatocafé en brazos y región escapulares, de ocho años de evolución que han crecido lentamente y algunas son dolorosas al tacto. Se le realizó biopsia y el estudio histológico reveló tumoraciones de células fusiformes, rectas, localizadas en la dermis que corresponden a células de músculo liso del músculo piloerector. (Rev Cost Cienc Med 1999; 20(3,4): 231-235) Palabras claves: Leiomioma, leiomioma pilar múltiple

Unusual abdominal tumors with intracardiac extension. Two cases with successful surgical resection

Abdominal tumors that can grow through vascular lumen and spread to the right heart are rare. Although these tumors have different histologic aspects, they may cause similar abdominal and cardiac symptoms and are a serious risk factor for pulmonary embolism and sudden death when they reach the right atrium and tricuspid valve. The best treatment is radical surgical resection of the entire tumor using cardiopulmonary bypass with or without deep hypothermia and total circulatory arrest. We report the cases of two patients, the first with leiomyosarcoma of the inferior vena cava and the other with intravenous leiomyomatosis of the uterus that showed intravascular growth up to right atrium and ventricle, who underwent successful radical resection in a one-stage procedure with the use of cardiopulmonary bypass. We discuss the clinical and histologic aspects and imaging diagnosis and review the literature

Leiomiomatosis peritoneal diseminada. Presentación de un caso y revisión de la literatura

Presentamos el caso de una mujer de 31 años a quien se le encontraron múltiples lesiones modulares intraperitoneales. La impresión diagnóstica intra-operatoria fue de Miomatosis peritoneal, la cual fue confirmada posteriormente con el estudio de anatomía patológica. La importancia de conocer esta lesión inusual, radica en realizar el diagnóstico diferencial con lesiones malignas metastásicas, pues la Leiomiomatosis Peritoneal Diseminada (LPD) tiene un curso y un pronóstico benigno. En esta revisión se discute ademas la patogenia, el manejo y el tratamiento de la LPD en relación con la paciente objeto de la presentación

Miomatosis de localización poco frecuente / Leiomyomata uteri of rare location

Se describen tres casos de pacientes en edad reproductiva, portadoras de miomatosis uterina de localización poco común. Pacientes de 37 años, con sangrado genital anormal, secundario a tumor cervical; ameritando HTA en 1993. Un año después se le efectuá exéresis de tumor que dependía de pared vaginal anterior. Paciente de 16 años que acude al servicio de Ginecología con diagnóstico de Bartholinitis. Se realizó exéresis de tumor en región vulvar. Paciente de 35 años con incontinencia urinaria de esfuerzo, hematuria y sensación de cuerpo extraño en vagina, la cual correspondía a tumor que dependía de uretra. Por lo que se realizó exéresis de dicho tumor. En los tres casos descritos se enviaron los tumores extirpados a estudio histopatológico; resultado; Miomatosis: vulvar, vaginal y uretral respectivamente

Piloleiomiona múltiplo: relato de caso com diagnóstico diferencial / Multiple piloleiomyoma: report of a case with differential diagnosis

Homem pardo, 51 anos de idade, com lesäo em placa eritematonodular extensa, dolorosa, pruriginosa, localizada na regiäo infra-escapular esquerda, há 10 anos. A microscopia da lesäo revelou excesso de fibras musculares lisas na derme, sem proliferaçäo de folículos pilosos e sem hipergimentaçäo epidérmica. Ocasionais folículos pilosos foram observados, alguns exibindo conexäo entre o músculo eretor do pêlo e as células neoplásicas. É analisado o diagnóstico diferencial entre lesöes dolorosas da pele e entre as caracterizadas por proliferaçäo dérmica de fibras musculares lisas

Leiomioma retroperitoneal: informe de un caso / Retroperitoneal leiomyoma: a case report

Los tumores benignos de músculo liso tienen una frecuencia muy alta en el tracto genitourinario y gastrointestinal y son muy raros en retroperitoneo. Se presenta el caso de una mujer de 37 años de edad con diagnóstico de miomatosis uterina en la que el hallazgo fue de leiomioma retroperitonea