RESUMO
Chicken pox is caused by Varicella zoster. Infected persons usually acquire permanent immunity and a reinfection is unusual. We report on a leukemic girl aged 12 years and 4 months, who had two chicken pox infections during 2 months. Leukemia was diagnosed 20 months ago. In her past history she had a first chicken pox infection 2 years before leukemia was diagnosed. Recurrence of chicken pox is possible especially in immune comprised individuals. Our leukemic patrent had 3 attacks of chicken pox
Assuntos
Humanos , Feminino , Leucemia/virologia , Recidiva , Hospedeiro Imunocomprometido , Herpesvirus Humano 3RESUMO
Parvovirus B19 has a marked tropism for erythroid progenitor cells. This may lead to chronic anemia in predisposed individuals. The purpose of the study was to investigate the frequency of parvovirus B19 infections in patients with diagnosis of haematological disorders. In order to determine the diagnostic use of different markers of parvovirus B19 infection, serum specimens obtained from 79 patients with haematological disorders were tested for specific antibodies and viral DNA through the use of ELISA and PCR techniques. Evidence of parvovirus B19 infection was found in 23/79 (29.1 percent) patients by demonstrating viral DNA and/or specific IgM antibody. B19 infection was established in 3 of 11 patients with chronic myeloid leukemia, in 3 of 11 acute myeloid leukemia, in 2 of 11 patients with multiple myeloma, in 3 of 8 patients with Hodgkin's lymphoma, in 5 of 10 patients with non-Hodgkin's lymphoma, in 1 of 6 patients with myelodysplastic syndrome, in 4 of 11 patients with chronic lymphocytic leukemia, and in 2 of 11 patients with acute lymphocytic leukemia. In 4 of 23 positive patients, only parvovirus B19 DNA could be detected, while 7 patients were tested positive for both parvovirus B19 DNA and specific IgM. Nine patients were tested positive for both B19 DNA and specific IgG. In the remaining 3 positive patients only specific IgM could be detected. Due to the discrepancies between DNA and IgM results, the diagnostic procedures should include a search for specific DNA by PCR methods if specific IgM has been found to be negative.
Assuntos
Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Hematológicas/virologia , Infecções por Parvoviridae/virologia , Doença Aguda , Anticorpos Antivirais/sangue , Doença Crônica , DNA Viral/análise , Ensaio de Imunoadsorção Enzimática , Doença de Hodgkin/virologia , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Leucemia/virologia , Linfoma não Hodgkin/virologia , Reação em Cadeia da Polimerase , Estudos Prospectivos , Infecções por Parvoviridae/diagnóstico , /genética , /imunologiaRESUMO
The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.
Assuntos
Humanos , Doença Aguda , Adenocarcinoma/virologia , Linhagem Celular , DNA Viral/genética , Coreia (Geográfico) , Leucemia/virologia , Vírus da Leucemia Bovina/genética , Leucemia-Linfoma Linfoblástico de Células Precursoras/virologia , Leucemia Mieloide/virologia , Leucemia Mielogênica Crônica BCR-ABL Positiva/virologia , Neoplasias Pulmonares/virologia , Reação em Cadeia da Polimerase/métodos , Provírus/genéticaAssuntos
Humanos , Animais , Fatores de Crescimento de Células Hematopoéticas/fisiologia , Regulação da Expressão Gênica , Hematopoese , Células-Tronco Hematopoéticas/fisiologia , Leucemia/genética , Leucemia/fisiopatologia , Leucemia/virologia , Linfoma/genética , Linfoma/fisiopatologia , Linfoma/virologia , Sistema Hematopoético/embriologiaRESUMO
Hepatitis delta virus [HDV] is a defective virus which requires hepatitis B virus as a helper virus. The present study was carried out on sera of 58 ALL children after induction chemotherapy for the detection of HBV markers and HDV antigen by enzyme linked immunosorbant assay [ELISA] technique. Of the 58 ALL cases, with a mean age of 5.8 years, 34 were positive for one or more of the HBV markers, 22 were positive for HBsAg, 13 were positive for HB anti- core IgM, 10 were positive for anti-HBs and 9 were positive for HbeAg. Of these 34 patients, 7 were found to be positive for HDV antigen. ALL 7 children showed elevated ALT levels, which was statistically significantly different when compared to HDAg negative children. On the other hand, 24 ALL children were negative for all HBV markers and were also negative for HD antigen. Co-infection of HBV and HDV was the prominent pattern of infection in these patients. As these leukemic children had received multiple transfusions during induction therapy, they became liable to acquire both viruses from infected blood