RESUMO
La coexistencia de enfermedades mieloproliferativas y linfoproliferativas en el mismo paciente no es común. La mayoría de los casos corresponden a pacientes que desarrollan leucemia aguda durante el curso evolutivo de una leucemia linfática crónica tratada con drogas quimioterápicas. Se presenta un caso de leucemia mielomonocítica aguda y leucemia linfática crónica B diagnosticadas simultáneamente en un paciente en el cual, el análisis por citometría de flujo utilizando un amplio panel de anticuerpos monoclonales, permitió identificar las diferentes poblaciones patológicas y determinar su inmunofenotipo característico. Una revisión de la bibliografía muestra solamente la descripción de casos aislados sin encontrar datos sobre la incidencia de esta asociación. Destacamos la utilidad de la técnica de citometría de flujo para identificar las células anormales que nos llevan al diagnóstico de estas dos enfermedades.
The coexistence of acute myeloid leukemia and chronic lymphocytic leukemia in the same patient is rare. The majority of the cases correspond to patients that developed acute leukemia during the evolutionary course of a chronic lymphatic leukemia following treatment with chemotherapy drugs. We report a case of acute myelomonocytic leukemia concurrent with untreated B-cell chronic lymphocytic leukemia in which the use of flow cytometry analysis with a large panel of monoclonal antibodies, allowed the demonstration of different pathological populations and determine immunophenotyping patterns. Published cases of simultaneous chronic lymphocytic leukemia and acute leukemia are reviewed. The use of multiparametric flow cytometry to differentiate the populations demonstrates the utility of this technology in the diagnosis of these hematological malignancies.
Assuntos
Idoso , Humanos , Masculino , Anticorpos Monoclonais/análise , Linfócitos B/patologia , Leucemia Linfocítica Crônica de Células B/patologia , Leucemia Mielomonocítica Aguda/patologia , Neoplasias Primárias Múltiplas/patologia , Linfócitos B/imunologia , Células Clonais , Citometria de Fluxo , Imunofenotipagem , Leucemia Linfocítica Crônica de Células B/imunologia , Leucemia Mielomonocítica Aguda/imunologia , Neoplasias Primárias Múltiplas/imunologiaRESUMO
A rare variant of a subgroup of acute non-lymphocytic leukaemia designated by the French-American-British Co-operative Group as acute myelomonocytic leukaemia with bone marrow eosinophilia is described. This variant, first described in 1982 has a distinct bone marrow morphology, a favourable prognosis and shows a unique chromosomal abnormality. This is the first documentation of the condition in Sri Lanka.
Assuntos
Medula Óssea/patologia , Eosinófilos/patologia , Feminino , Humanos , Leucemia Mielomonocítica Aguda/patologia , Pessoa de Meia-IdadeRESUMO
We describe a young adult male with granulocytic sarcoma of the paranasal sinuses and nose with acute non-lymphoblastic leukaemia. Complete remission was achieved after systemic chemotherapy and localised radiation therapy. The patient died four months later due to disseminated aspergillosis.