Senior Managed Care System for Hip Fracture in the United States

BACKGROUND: It is debatable whether a managed care model would affect the quality of care and length of hospital stay in the treatment of hip fractures in elderly patients. METHODS: This prospective study was undertaken to determine whether or not a managed care critical pathway tool shortened hospital stay in a group of 102 senior patients with fractures of the hip during follow-up. We compared our study findings with two equivalent populations of senior hip fracture patients not treated using a critical care pathway concerning specific markers of quality. RESULTS: The managed care group had a 9% mortality rate, 95% return to prefracture living and 63% return to ambulatory status. The rates compared favorably with previous studies. The quality of care provided before and after the critical pathway was equivalent, while the post-pathway length of stay dropped 30%. CONCLUSIONS: The proposed care protocol is recommended to shorten hospital stay in elderly patients with hip fractures.

Cuatro cuestiones axiológicas de la epidemiología social para el monitoreo de la desigualdad en salud / Four axiological considerations in social epidemiology for the monitoring of health inequality

A medida que las agendas contemporáneas más relevantes de la salud pública mundial y regional se van alineando en sus componentes conceptuales y emerge más explícitamente el rol medular de la equidad como su principio constitutivo, va creciendo también el reconocimiento del valor estratégico del monitoreo de desigualdades sociales en salud como el instrumento por excelencia de la inteligencia sanitaria para juzgar objetivamente el progreso hacia la equidad en salud, pero también para dar cuenta de la acción sobre los determinantes sociales de la salud, el avance hacia el alcance progresivo de la universalidad en salud y el éxito de iniciativas intersectoriales con enfoque de salud en todas las políticas. Estas transformaciones acontecen en el marco de una cada vez más evidente transición paradigmática de la salud pública. Este ensayo plantea cuatro consideraciones axiológicas inherentes a-y esenciales para-la conceptualization e instrumentación de la medición y monitoreo de las desigualdades en salud: la ecoepidemiología como era emergente en la salud pública contemporánea, los determinantes de la salud como modelo de causalidad y núcleo del nuevo enfoque paradigmático, la relación entre jerarquía social y salud para entender el gradiente en salud, y la necesidad práctica de una clasificación socioeconómica para capturar la dimensión social de la determinación de la salud. Se plantea que estas cuatro cuestiones valorativas otorgan coherencia y racionalidad epidemiológicas al proceso de medición y monitoreo de las desigualdades en la salud y, por extensión, a la formulación de propuestas de política sanitaria en pro de la equidad.

As the conceptual components of the most important contemporary public health agendas at the global and regional levels are brought into alignment and as it becomes more clearly understood that equity is a constitutive principle of these agendas, there is also a growing awareness of the strategic value of monitoring social inequalities in health. This is the health intelligence tool par excellence, not only for objectively assessing progress towards achieving health equity, but also for reporting action on the social determinants of health, progress towards the attainment of health for all, and the success of intersectoral efforts that take a "health in all policies" approach. These transformations are taking place in the context of an increasingly evident paradigm shift in public health. This essay presents four axiological considerations inherent to-and essential for -conceptualizing and implementing ways to measure and monitor health inequalities: ecoepidemiology as an emerging field in contemporary public health; the determinants of health as the causal model and core of the new paradigm; the relationship between the social hierarchy and health to understand the health gradient; and the practical need for a socioeconomic classification system that captures the social dimension in the determinants of health. The essay argues that these four axiological considerations lend epidemiologic coherence and rationality to the process of measuring and monitoring health inequalities and, by extension, to the development of pro-equity health policy proposals.

Gene cloning, expression, and characterization of the Bacillus amyloliquefaciens PS35 lipase

Abstract Lipases are enzymes of immense industrial relevance, and, therefore, are being intensely investigated. In an attempt to characterize lipases at molecular level from novel sources, a lipase gene from Bacillus amyloliquefaciens PS35 was cloned, heterologously expressed in Escherichia coli DH5α cells and sequenced. It showed up to 98% homology with other lipase sequences in the NCBI database. The recombinant enzyme was then purified from E. coli culture, resulting in a 19.41-fold purification with 9.7% yield. It displayed a preference for long-chain para-nitrophenyl esters, a characteristic that is typical of true lipases. Its optimum pH and temperature were determined to be 8.0 and 40 °C, respectively. The half-lives were 2.0, 1.0 and 0.5 h at 50 °C, 60 °C and 70 °C, respectively. The metal ions K+ and Fe3+ enhanced the enzyme activity. The enzyme displayed substantial residual activity in the presence of various tested chemical modifiers, and interestingly, the organic solvents, such as n-hexane and toluene, also favored the enzyme activity. Thus, this study involves characterization of B. amyloliquefaciens lipase at molecular level. The key outcomes are novelty of the bacterial source and purification of the enzyme with desirable properties for industrial applications.

The ethics in qualitative health research: special considerations / A ética na pesquisa qualitativa em saúde: considerações especiais

AbstractA sound knowledge of the nature of qualitative research, along with an appreciation of some special ethical considerations, is needed for rigorous reviews to be conducted. The overall character of qualitative research is described with an emphasis on the tendency of qualitative researchers to explore sensitive topics using theoretically informed methods. A number of specific features of qualitative that require additional ethical attention and awareness are also examined including the following: 1) participants are frequently quite vulnerable and require protection because the data collection methods, such as in-depth interviews, can delve into personally and politically charged matters; 2) naturalistic observation can raise concerns regarding privacy and consent; 3) the potential for the identifiability of the results of this research may require extra efforts to maintain confidentiality. Ultimately, Reseach Ethics Committee members must be knowledgeable about qualitative approaches to be able to assess the potential harms and benefits in a protocol carefully. Without this knowledge gaining ethics approval can be overly difficult for researchers and the best practices for protecting human participants can be overlooked.

ResumoO caráter geral da pesquisa qualitativa é descrito com ênfase na tendência de pesquisadores qualitativos para explorar temas sensíveis, utilizando métodos teoricamente informados. Algumas características específicas de pesquisa qualitativa que requerem consciência e atenção ética adicional também são examinadas, incluindo as seguintes: 1) frequentemente os participantes são bastante vulneráveis e necessitam de proteção porque os métodos de coleta de dados, tais como entrevistas em profundidade, podem levar a uma profunda análise de questões repletas de aspectos pessoais e políticos; 2) a observação naturalística pode levantar questões específicas em matéria de privacidade e consentimento; 3) o potencial de que os resultados da pesquisa possibilitem a identificação dos participantes exige esforços adicionais para proteger a privacidade deles. Em última análise, os membros dos Comitês de Ética em Pesquisa (CEP) devem conhecer as abordagens qualitativas para avaliar cuidadosamente os potenciais danos e benefícios em um protocolo. Sem esse conhecimento, a aprovação ética pode ser excessivamente difícil para os pesquisadores e as melhores práticas para proteger os participantes podem ser negligenciadas.

Suicide notes from Mexico and the United States: a thematic analysis / Notas suicidas de México y Estados Unidos: un análisis temático

OBJECTIVE: This study sought to investigate suicide notes drawn from Mexico and the United States (US) as these countries share geographical proximity, but markedly different cultures and suicide rates. MATERIAL AND METHODS: A theoretical conceptual analysis of 102 suicide notes drawn from these countries, matched for age and sex, was undertaken based on a thematic model of suicide developed by Leenaars,1,2 across countries. RESULTS: The inter-judge reliability was adequate (.86 coefficient of concordance). CONCLUSIONS: The results suggested that there are more psychological commonalities than differences. Yet, as this study marks the first one using suicide notes, between Mexico and the USA, much greater study is warranted.

OBJETIVO: Este estudio tuvo por objetivo la comparación de notas suicidas (póstumas) de México y de Estados Unidos, países que aunque vecinos geográficos, presentan marcadas diferencias culturales y porcentajes de suicidio. MATERIAL Y MÉTODOS: Se realizó un análisis conceptual de 102 notas (51 mexicanas, 51 estadunidenses), pareadas por edad y sexo. Se utilizó el Modelo temático de suicidio desarrollado por Leenaars1,2 y que ha sido la base de varios estudios en diversos países. RESULTADOS: La técnica de Análisis de contenido obtuvo un adecuado nivel de concordancia (86%) con el Método de interjueces. CONCLUSIONES: Los resultados informan que existen más semejanzas que diferencias psicológicas entre ambas muestras. El presente es el primer estudio que utiliza notas suicidas entre ambos países.

Sexual solicitation of Latino male day laborers by other men / Solicitación sexual de hombres jornaleros latinos por otros hombres

OBJECTIVE: To examine the likelihood of Latino day laborers being solicited for sex by other men. MATERIAL AND METHODS: 450 Latino day laborers were recruited in Los Angeles, California, from July to September 2005. Logistic regression analysis was used to determine which day laborers were more likely to be solicited and subsequently to have sex. RESULTS: Thirty-eight percent reported being solicited for sex by another man while seeking work. Those solicited were more likely to live longer in the US, be more educated and screen positive for drug dependence. Of those solicited, 9.4 percent had sex with their solicitors. Those screening positive for drug dependence were more likely to have sex. Most of the day laborers who had anal sex with their solicitors did not always use condoms. CONCLUSIONS: HIV prevention efforts should target drug dependent day laborers, who may place themselves at risk for HIV through sex with male solicitors.

OBJETIVO: Examinar hasta qué punto los jornaleros latinos son solicitados por otros hombres para tener relaciones sexuales. MATERIAL Y MÉTODOS: Cuatrocientos cincuenta jornaleros latinos fueron reclutados en Los Ángeles, California, de julio a septiembre de 2005. Un análisis de regresión logística fue utilizado para determinar cuáles jornaleros tenían más probabilidades de que fueran solicitados y, subsecuentemente, de que tuvieran sexo. RESULTADOS: Treinta y ocho por ciento reportaron que fueron solicitados para sexo por otros hombres mientras buscaban trabajo. Estos hombres que fueron solicitados tenían más probabilidades de haber vivido más tiempo en los Estados Unidos, tener más educación formal y dar resultados positivos en dependencia de drogas. De los solicitados, 9.4 por ciento tuvieron sexo con los solicitadores. Aquellos que dieron resultados positivos para dependencia de drogas tenían más probabilidades de tener sexo. La mayoría de los jornaleros que tuvieron sexo anal con los solicitadores no siempre usaron condón. CONCLUSIONES: Esfuerzos de prevención del VIH deben dirigirse a jornaleros dependientes de drogas quienes pueden estar exponiéndose al riesgo de contraer VIH al tener sexo con solicitadores masculinos.