Unusual Course of Acne Conglobata as a Skin Manifestation due to Bilateral Luteoma of Pregnancy

No abstract available.

Luteoma del embarazo. Reporte de caso / Luteoma of pregnancy. A case report

Luteoma of pregnancy is an infrequent non-neoplastic pathology of the ovary. It is usually an incidental finding during the evaluation of a pregnant patient in the third trimester or during a cesarean section. Occasionally, it may raise suspicion of cancer, resulting in unnecessary surgical resection of the ovary. We present the case of a 34-year-old woman who was in her third pregnancy and during the cesarean section, a 9 cm tumor of the right ovary was incidentally found and resected. The histological study was compatible with luteoma of pregnancy.

El luteoma del embarazo es una patología no neoplásica del ovario, de incidencia poco frecuente. Suele presentarse como hallazgo incidental durante la evaluación de una paciente embarazada en el tercer trimestre o en el momento del acto quirúrgico de una cesárea. En ocasiones, puede llevar a sospechar una neoplasia maligna, derivando así en una resección quirúrgica innecesaria del ovario. Presentamos el caso de una mujer de 34 años que cursaba su tercera gestación y a quien, durante la cesárea, se le halló una tumoración ovárica derecha de 9 cm de diámetro que fue resecada. El estudio histológico fue compatible con luteoma del embarazo.

A Case of Ovarian Steroid Cell Tumor, Not Otherwise Specified, Treated with Surgery and Gonadotropin Releasing Hormone Agonist

Steroid cell tumors account for less than 0.1% of all ovarian tumors. There are three steroid cell tumor subtypes: steroid cell tumor not otherwise specified (NOS), stromal luteoma and Leydig cell tumor. Steroid cell tumor, NOS, is the most common type and has malignant potential. This report describes a case of an ovarian steroid cell tumor, NOS. A 35-year-old woman visited hospital with the complaint of metrorrhagia. Physical examination revealed increased pubic hair. Transvaginal ultrasound indentified a 4.9 x 3.4 cm, well-circumscribed and solid left ovarian tumor. After laparoscopic left oophorectomy, the tumor was revealed as an ovarian steroid cell tumor, NOS. During the laparoscopic surgery, tumor ruptured. Complete surgical staging was performed and no evidence of metastasis was found. Gonadotropin releasing hormone agonist was administered monthly for 6 months. The patient has had no evidence of recurrence for 43 months.

Ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal hirsute woman / Deficiência de 21-hidroxilase ovariana intratumoral na virilização da mulher pós-menopausa

Virilising ovarian tumours are a rare cause of hyperandrogenism in women, accounting for less than 5% of all ovarian neoplasms. It occurs most often in - and postmenopausal women. We report a case of a 64 year-old woman with signs of virilisation that had started 3 years before. Blood hormone analysis revealed increased levels of testosterone, and 17-hydroxyprogesterone. The tetracosactin test revealed 21-hydroxylase deficiency. Radiological imaging demonstrated a nodule in her left ovary. The patient was submitted to bilateral laparoscopic oophorectomy, and histopathological examination revealed a luteoma of the left ovary. Postoperative serum testosterone level and 17-hydroxyprogesterone returned to normal levels in one month. Virilism regressed within six months. Our patient also showed an elevation in 17-OHP serum levels. Normalization of 17-OHP after oophorectomy suggests a case of intratumoral 21-hydroxylase deficiency. To our knowledge, this is the first description of ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal woman. Arq Bras Endocrinol Metab. 2012;56(9):672-6.

Tumores ovarianos virilizantes são uma causa rara de hiperandrogenismo em mulheres, contabilizando menos de 5% de todos as neoplasias ovarianas. Esses tumores ocorrem mais comumente em mulheres em peri ou pós-menopausa. Relatamos aqui o caso de uma mulher de 64 anos de idade com sintomas de virilização que começaram 3 anos antes. O perfil hormonal revelou níveis aumentados de testosterona e de 17-hidroxiprogesterona (17-OHP). O teste de tetracosactin demonstrou deficiência de 21-hidroxilase. Exames radiológicos mostraram um nódulo no ovário esquerdo. A paciente foi submetida à ooforectomia laparoscópica bilateral e o exame histopatológico revelou um luteoma no ovário esquerdo. A concentração sérica de testosterona e de 17-hidroxiprogesterona após a cirurgia retornou aos níveis normais em um mês. A virilização regrediu em 6 meses. Nossa paciente também revelou uma elevação dos níveis séricos de 17-OHP. A normalização da 17-OHP após a ooforectomia sugere um caso de deficiência de 21-hidroxilase intratumoral. Esta é a primeira descrição de deficiência de 21-hidroxilase intratumoral em uma mulher na pós-menopausa. Arq Bras Endocrinol Metab. 2012;56(9):672-6.

Luteoma gestacional não virilizante simulando neoplasia ovariana / Pregnancy luteoma without virilization mistaken by an ovarian tumor

Objetivo: descrever um caso de ooforectomia em paciente com luteoma gestacional, um pseudotumor ovariano relacionado a uma resposta exagerada do estroma ovariano aos hormônios da gravidez que regride após o parto. Relato do caso: mulher de 42 anos, em sua terceira gestação, evoluiu sem intercorrências. Durante a realização de cesariana, observou-se a existência de tumoração ovariana bilateral, sendo realizada ooforectomia. A análise histopatológica demonstrou-se tratar-se de um luteoma gestacional. Considerações finais: por não constituir um tumor verdadeiro e pela tendência à regressão no pós-parto, readquirindo as dimensões normais, deve-se avaliar com cautela a realização de ooforectomias em pacientes gestantes que apresentem aumento das dimensões ovarianas.

Purpose:to report a case of pregnancy luteoma, an ovarian pseudotumors usually diagnosed during cesarian section or at postdelivery tubal ligation. After delivery the ovary size returns to normal in a few weeks. Case Report: A 46 year old female,(G 3, P 2) without complains. During cesarian section It was noticed an increase of the ovarian size, the approch was bilateral ooforectomy.The histhopathological diagnostic was pregnancy luteoma .Final Considerations: being just a pseudotumor that decrease after delivery the surgeon must remember this nosological entity, that is easily mistaken by true ovarian tumors, and try to avoid an ooforectomy.

Luteoma of pregnancy

Virilization in female newborns as a result of an ovarian mass known as luteoma of pregnancy is a rare condition. A case of a maternal pregnancy luteoma responsible for virilization of both newborn and mother is reported. Luteoma of pregnancy, first described by Sternberg in 1963, is usually asymptomatic and is discovered incidentally during a cesarean section or postpartum tubal ligation. To date, fewer than 200 cases have been reported in the literature. This report describes a case of a virilized pregnant woman first seen in active labor who eventually underwent cesarean section for arrest of descent. Intraoperative findings showed a well circumscribed, pedunculated mass attached to the left ovary. A healthy baby girl was born with masculinization of the external genitalia.

Stromal luteoma: report of a rare case.

Steroid cell tumours (SCTs) account for less than 0.1% of all ovarian tumours. Three major categories ofSCTs include (1) stromal luteoma, (2) steroid cell tumour not otherwise specified and (3) Leydig cell tumours that do not have another component. Stromal luteomas constitute 20% of SCTs. They usually occur in postmenopausal women and about 60% present with estrogenic manifestations. We report a case of stromal luteoma in an elderly lady who presented with postmenopausal bleeding secondary to endometrial hyperplasia. An interesting finding in our case was the presence of many eosinophilic hyaline globules scattered throughout the tumour, the significance of which remains to be determined.

MR Imaging of Pregnancy Luteoma: a Case Report and Correlation with the Clinical Features

We report here on a 26-year-old pregnant female who developed hirsutism and virilization during her third trimester along with a significantly elevated serum testosterone level. Abdominal US and MR imaging studies were performed, and they showed unique imaging features that may suggest the diagnosis of pregnancy luteoma in the clinical context. After the delivery, the serum testosterone level continued to decrease, and it returned to normal three weeks postpartum. The follow-up imaging findings were closely correlated with the clinical presentation.

A Case of Ovarian Steroid Cell Tumor with Obesity / 대한산부인과학회잡지

Ovarian steroid cell tumors are composed exclusively of cells that have the histologic features of steroid hormone secreting cells. And these are rare lesions and have been divided into four subtyes according to their size, location in the ovary, and presence or absence of crystals of Reinke in the cytoplasm as follows: stromal luteomas, hilus cell tumors, Leydig cell tumors (non-hilar type), and steroid cell tumors not otherwise specified. Steroid cell tumors often secret androgens, and manifest themselves with symptoms of virilization. Other presenting manifestations include hirsutism, amenorrhea, obesity, hypertension and alopecia. We experienced a case of ovarian steroid cell tumor, manifested by obesity and amenorrhea and present with a brief review of the literatures.

Luteoma recorrente da gravidez com virilizaçäo materna e fetal / Recurrent luteoma of pregnancy with maternal and fetal virilization

Os luteomas da gravidez säo pseudotumores ovarianos diagnosticados pelo exame ultra-sonográfico ou durante realizaçäo de cesariana e laqueadura pós-parto. Determinam, na segunda metade da prenhez, sinais de virilizaçäo materna em um quarto dos casos, o mesmo ocorrendo com a metade dos fetos femininos destas gestantes virilizadas nos quais se observa hipertrofia clitoridiana ou fusäo labial. As dosagens séricas maternas dos hormônios androgênicos durante a prenhez e do sangue umbilical por ocasiäo do parto revelam taxas significativamente aumentadas. No exame ultra-sonográfico apresentam-se como estruturas sólidas ou cístico-sólidas, que após o parto tendem a regredir com o ovário readquirindo as dimensöes normais em poucas semanas. Os autores apresentam uma paciente que em duas gestaçöes sucessivas apresentou virilizaçäo materna e fetal. Ao exame ultra-sonográfico foram evidenciadas imagem ovariana nodular e dosagens elevadas dos androgênios plasmáticos.

Quiste folicular gigante luteinizado del embarazo y el puerperio. Presentación de un caso y revisión de la literatura / Large luteinized follicle cyst of pregnancy and puerperium. A case report and review of the literature

Mujer de 23 años con embarazo de 37 semanas de EG y diagnóstico ecográfico de masa quística anexial derecha clínicamente benigna, quien fue llevada a cesárea para atención del parto y resección de la masa. El estudio anatomopatológico del tumor mostró un quiste folicular gigante solitario luteinizado (QFGSL) del embarazo. El manejo quirúrgico de la paciente fue conservador, con una evolución adecuada y óptimo pronósico. Se discuten los aspectos referentes a la historia natural de la enfermedad, las características anatomatológicas y la posible patogenia

Luteoma estromal como causa de hirsutismo pós-menopausa / Estromal luteoma due post menopausal hirsutism

O objetivo deste trabalho é apresentar um caso de hirsutismo após a menopausa, provocado por um tumor de células esteróides (luteoma estromal) do ovário, atendido no Centro de Atendimento Integral à Saúde da Mulher (CAISM) da UNICAMP. Trata-se, geralmente, de um tumor benigno, pequeno e que ocorre com maior freqüência em mulheres idosas. Os autores chamam a atençao para a suposiçao diagnóstica de tumor ovariano em uma mulher após a menopausa com níveis elevados de testosterona, na qual afastou-se a possibilidade de tumor adrenal, mesmo sem haver um diagnóstico imagenológico prévio.