RESUMO
Our objective was to investigate the distributions of six single nucleotide polymorphisms (SNPs) MS4A2 E237G, MS4A2 C-109T, ADRB2 R16G, IL4RA I75V, IL4 C-590T, and IL13 C1923T in Mauritian Indian and Chinese Han children with asthma. This case-control association study enrolled 382 unrelated Mauritian Indian children, 193 with asthma and 189 healthy controls, and 384 unrelated Chinese Han children, 192 with asthma and 192 healthy controls. The SNP loci were genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism for the Chinese Han samples and TaqMan real-time quantitative PCR for the Mauritian Indian samples. In the Mauritian Indian children, there was a significant difference in the distribution of IL13 C1923T between the asthma and control groups (P=0.033). The frequency of IL13 C1923T T/T in the Mauritian Indian asthma group was significantly higher than in the control group [odds ratio (OR)=2.119, 95% confidence interval=1.048-4.285]. The Chinese Han children with asthma had significantly higher frequencies of MS4A2 C-109T T/T (OR=1.961, P=0.001) and ADRB2 R16G A/A (OR=2.575, P=0.000) than the control group. The IL13 C1923T locus predisposed to asthma in Mauritian Indian children, which represents an ethnic difference from the Chinese Han population. The MS4A2 C-109T T/T and ADRB2 R16G A/A genotypes were associated with asthma in the Chinese Han children.
Assuntos
Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Adulto Jovem , Povo Asiático/genética , Asma/genética , Predisposição Genética para Doença/etnologia , Polimorfismo de Nucleotídeo Único/genética , Asma/epidemiologia , Asma/etnologia , Estudos de Casos e Controles , Causalidade , China/epidemiologia , China/etnologia , Estudos de Associação Genética , Loci Gênicos , Genótipo , Predisposição Genética para Doença/epidemiologia , /genética , /genética , /genética , Maurício/epidemiologia , Maurício/etnologia , Polimorfismo de Fragmento de Restrição , Reação em Cadeia da Polimerase em Tempo Real , /genética , Receptores de IgE/genéticaRESUMO
OBJECTIVE: To study cervical smear abnormalities in urban women in India and women in Mauritius and to compare the results in the two groups. STUDY DESIGN: An analysis of 6010 cervical smears taken as part of routine check-ups in an urban hospital was done and an analysis of 10,000 cervical smears taken from women participating in a National Cancer Screening Program in Mauritius was done. Emphasis was put on cervical epithelial cell abnormalities and the results in the two populations are compared with that of similar studies in other parts of the world. RESULTS: Non specific inflammation formed 19.6% and 25.34% of the smears in the Indian and Mauritian groups, respectively (with specific infection forming 6.05% and 15.08%). The epithelial abnormalities constituted 1.392% of the Indian group and 0.47% of the Mauritian group. The difference was statistically significant in the atypical squamous cells of uncertain significance (ASCUS) and atypical glandular cells of uncertain significance (AGUS) group. CONCLUSIONS: The prevalence of low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL) is similar to that in the developed world.
Assuntos
Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Hospitais Urbanos , Humanos , Índia/epidemiologia , Programas de Rastreamento/métodos , Maurício/epidemiologia , Pessoa de Meia-Idade , Neoplasias de Células Escamosas/epidemiologia , Prevalência , Índice de Gravidade de Doença , Neoplasias do Colo do Útero/epidemiologia , Esfregaço Vaginal , Vaginite/epidemiologia , Adulto JovemRESUMO
OBJECTIVE: To determine the seroprevalence of CMV antibodies in the Mauritian volunteer blood donor population and to establish a panel of CMV-seronegative blood donors. STUDY SUBJECTS AND METHODS: Five hundred and eighty four apparently healthy blood donors were screened for evidence of CMV infection by the complement fixation test. There were 551 males and 33 females with age ranging from 18 to 60 years. RESULTS: Complement-fixing antibodies were found in 93.5% of the blood donors. The prevalence was 93.1% in males and 100% in females. CONCLUSION: Our findings demonstrate that seroprevalence of CMV in the local blood donors is very high making CMV-seronegative blood very scarce. Therefore leucocyte-depleted blood should be used as an alternative to CMV-seronegative blood during transfusions.