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Asian Pac J Allergy Immunol ; 2003 Sep; 21(3): 145-51
Artigo em Inglês | IMSEAR | ID: sea-36811

RESUMO

The aim of this study was to investigate the effects of human tryptases on inflammatory cell accumulation in vivo. Various concentrations of purified lung or skin tryptases were injected into the peritoneum of BALB/c mouse. At 6 hours or 16 hours following injection, cells from the peritoneal lavage were collected and stained with modified Wright's stain. Differential cell counts were performed and results were expressed as absolute numbers of each cell type per mouse peritoneum. The results showed a dose-dependent infiltration of neutrophils with a maximal increase of up to 32 fold or 43 fold in numbers at 16 hours following an injection of skin and lung tryptases, respectively. Skin tryptase was able to attract more eosinophils than lung tryptase. Significant increases in lymphocyte and macrophage numbers were also observed. In conclusion, both skin and lung tryptases are able to induce nucleated cell accumulation in the peritoneum of mice with similar specificity and potency.


Assuntos
Indutores da Angiogênese/administração & dosagem , Animais , Anticoagulantes/farmacologia , Diferenciação Celular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Heparina/farmacologia , Mediadores da Inflamação/administração & dosagem , Injeções Intravenosas , Pulmão/enzimologia , Linfócitos/citologia , Macrófagos/citologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Modelos Animais , Infiltração de Neutrófilos/efeitos dos fármacos , Neutrófilos/citologia , Peritônio/citologia , Serina Endopeptidases/administração & dosagem , Pele/enzimologia , Triptases
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