Studies on the methodology for quality control in Chinese medicine manufacturing process based on knowledge graph / 中国中药杂志

According to the requirements for developing the quality control technology in Chinese medicine( CM) manufacturing process and the practical scenarios in applying a new generation of artificial intelligence to CM industry,we present a method of constructing the knowledge graph( KG) for CM manufacture to solve key problems about quality control in CM manufacturing process.Based on the above,a " pharmaceutical industry brain" model for CM manufacture has been established. Further,we propose founding the KG-based methodology for quality control in CM manufacturing process,and briefly describe the design method,system architecture and main functions of the KG system. In this work,the KG for manufacturing Shuxuening Injection( SXNI) was developed as a demonstration study. The KG version 1. 0 platform for intelligent manufacturing SXNI has been built,which could realize technology leap of the quality control system in CM manufacturing process from perceptual intelligence to cognitive intelligence.

Viewpoint regarding "concise" of "classical formula" from case / 中国中药杂志

"Classical formula" are praised for their exact clinical efficacy,but many scholars of " classical formula" still remain in the simple symptoms and the superficial form of formula matching,failing to explore the connotation of " classical formula" in a subtle and in-depth way. The clinical curative effect and charm of " classical formula" mainly lie in " concise". " Concise" can be divided into many aspects,including " correspondence of formula and syndrome" infers pointing accuracy, " Classic formula" infers structure refining,and " pattern differentiation" infers process elaborating,ect. " Correspondence of formula and syndrome" requires doctors to take into account multiple factors such as physical characteristics,symptom features,diet taste and emotional preference of patients,so as to grasp its essence more accurately. " Classic formula" implies paying special attention to its composition and various methods of addition and subtraction. Not following Zhang Zhongjing's method and gilding the lily will affect the clinical efficacy. " Pattern differentiation" indicates doctors should separate Yin and Yang,examine syndrome features and distinguish the categories following the method of traditional Chinese medicine with comprehensive observation and comprehensive consideration in-depth so as to accurately select the appropriate prescription and improve the clinical efficacy.