Avaliação clínica e laboratorial de cão com osteoartrose tratado com formulação de meloxicam em spray oral. Relato de caso / Clinical and laboratory evaluation of a dog with osteoarthritis treated with oral spray meloxicam formulation. Case report / Avaliación clínica y de laboratorio de un perro con osteoartrosis tratado con formulación de meloxicam en spray oral. Reporte de caso

O presente relato de caso avaliou o meloxicam solução oral spray com o sistema de absorção transmucosa no tratamento de um cão tripedal acometido por osteoartrose em joelho e coluna. Além da avaliação ortopédica, foram realizados questionários de avaliação de dor, baropodometria, termografia e monitoramento de atividade.

The present case report evaluated the meloxicam oral solution spray with the transmucosal absorption system in the treatment of a three-legged dog affected by osteoarthritis in the knee and spine. In addition to the orthopedic evaluation, assessments of pain, baropodometry, thermography, and activity monitoring were carried out.

El presente informe de caso evaluó el spray de solución oral de meloxicam con el sistema de absorción transmucosa en el tratamiento de un perro de tres patas afectado por osteoartritis en la rodilla y columna. Además de la evaluación ortopédica, se realizaron cuestionarios de evaluación del dolor, baropodometría, termografía y monitoreo de la actividad.

The analgesic effect of preventive administration of meloxicam in calves submitted to hot-iron dehorning / Efeito analgésico da administração preventiva de meloxicam em bezerros submetidos à descorna com ferro quente

Dehorning is a zootechnical practice that causes severe pain in cattle. Although there are several studies evaluating the effects of analgesics in calf dehorning, none of them used validated pain assessment instruments. We evaluated the analgesic effectiveness of meloxicam administered before dehorning, compared to a control group, using the Unesp-Botucatu, numerical, simple descriptive, and visual analogue scales for pain assessment before and 4, 8, and 24 hours after the dehorning in 44 female calves. All calves received 0.04 mg/kg of xylazine IM 20 minutes before dehorning and local anesthetic block with 2% lidocaine with a vasoconstrictor. Calves were divided into two groups: without (GX; n = 22) or with 0.5 mg/kg of meloxicam (GXM; n = 22) administered intravenously before the procedure. Dehorning was performed through the section of the base of the horn bud, followed by thermocautery disbudding. For comparisons over time, mixed linear or generalized mixed linear model were used. The interaction between groups and study phases was used as fixed effects and each calf as a random effect. Bonferroni post hoc test was used. There was an increase in the pain scores at 4h compared to baseline in both groups (GX and GXM) for the four scales. The scores at 4h were higher in GX compared to GXM for all scales. Meloxicam reduced, but did not eliminate, behavioral expressions of pain in calves submitted to hot-iron dehorning. Therefore, it should be included in the analgesic protocol to improve welfare in calves undergoing dehorning.

A descorna é uma prática zootécnica que causa dor intensa em bovinos. Há na literatura diversos estudos sobre os efeitos de analgésicos para mitigar a dor frente a descorna, mas nenhum usando escalas validadas. Avaliamos a eficácia do meloxicam administrado previamente à descorna, comparado a um grupo controle, utilizando-se as escalas Unesp-Botucatu, numérica, simples descritiva e analógica visual para avaliação da dor antes e 4, 8 e 24 horas após a descorna em 44 bezerros fêmeas tratadas com 0,04 mg/kg de xilazina IM 20 minutos antes da descorna e bloqueio anestésico local com lidocaína a 2% com vasoconstritor. Os bezerros foram alocados em dois grupos: sem (GX; n=22) ou com 0.5 mg/kg de meloxicam (GXM; n=22) administrado por via intravenosa antes do procedimento. Realizou-se a descorna por secção da base do botão cornual seguido de termocauterização. Para as comparações ao longo do tempo, empregou-se o modelo linear ou linear misto. Considerou-se a interação entre grupos e momentos como efeito fixo e cada bezerro como efeito aleatório. As alterações foram inferidas de acordo com o pós-teste de Bonferroni. Para as quatro escalas houve aumento dos escores às 4h comparado ao basal em ambos os grupos (GX e GXM). Os escores de todas as escalas às 4h foram maiores em GX que em GXM. O meloxicam reduziu, mas não aboliu, a expressão comportamental da dor em bezerros submetidos à descorna com ferro quente, o que sugere o uso de terapia antálgica multimodal para realizar tal procedimento e garantir o bem-estar animal.

Effects of omega-6/3 and omega-9/6 nutraceuticals on pain and fertility in peritoneal endometriosis in rats

Abstract Purpose: To evaluate the effects of the nutraceuticals omega-6/3 and omega-9/6 on endometriosis-associated infertility and pain. Methods: Controlled experimental study, with each group composed of eight female rats. Fertility groups: sham-operated control (0.9% saline solution); control with endometriosis (0.9% saline); omega-6/3 (1.2 g/kg/day); omega-9/6 (1.2 g/kg/day); and meloxicam (0.8 mg/kg/day). Pain groups: sham-operated control (0.9% saline); control with endometriosis (0.9% saline); omega-6/3 (1.2 g/kg/day); omega-9/6 (1.2 g/kg/day); medroxyprogesterone acetate (5 mg/kg/every 3 days); and meloxicam (0.8 mg/kg/day). Peritoneal endometriosis was surgically induced. Pain was evaluated with the writhing test. Fertility was evaluated by counting the number of embryos in the left hemi-uterus. Results: The mean number of writhings was as follows: sham-operated, 11.1 ± 2.9; control with endometriosis, 49.3 ± 4.4; omega-6/3, 31.5 ± 2.7; omega-9/6, 34.1 ± 4.5; medroxyprogesterone acetate, 2.1 ± 0.8; meloxicam, 1 ± 0.3. There was a significant difference between both controls and all drugs used for treatment. Regarding fertility, the mean values were as follows: sham-operated, 6.8 ± 0.6; control with endometriosis, 4.2 ± 0.7; omega-6/3, 4.7 ± 1; omega-9/6, 3.8 ± 0.9; and meloxicam, 1.8 ± 0.9. Conclusions: The omega-6/3 and omega-9/6 nutraceuticals decreased pain compared to the controls. There was no improvement in fertility in any of the tested groups.

Associação terapêutica de dexametasona e meloxicam no controle inflamatório, após cirurgias de terceiros molares / Combination therapeutic dexamethasone and meloxicam in inflammatory controlafter third molars surgery

Os corticosteroides (CS) e anti-inflamatórios não esteroides (AINES) têm sido usados na busca do controle de processos inflamatórios em pacientes submetidos a cirurgias. O objetivo deste estudo foi avaliar o efeito entre o uso exclusivo de dexametasona e a associação desta e meloxicam no controle de edema, trismo e dor após selecionaram se cirurgias de terceiros molares inclusos. 15 pacientes com terceiros molares mandibulares inclusos (3MI) em posições simétricas, divididos por sorteio em grupos terapêuticos (GT). No grupo 1(GT1), receberam dose única via oral de 12 mg de dexametasona uma hora antes do procedimento cirúrgico; grupo 2 (GT2), 12 mg de dexametasona uma hora antes do procedimento cirúrgico e 15 mg de meloxicam no pós-operatório imediato por via oral, mantido a cada 24 horas, durante 3 dias. O edema e trismo foram avaliados, respectivamente, através de mensurações lineares da face e da distância interincisal pré e pós-operatória (24, 48 e 72h). A intensidade de dor foi avaliada através da escala visual analógica (EVA). Os dados foram submetidos ao teste t-student e teste Levene (p<0,05). As medidas de edema e trismo não apresentaram diferenças estatisticamente significativas. A associação resultou em menor intensidade de dor com diferença estatisticamente significativa. Concluiu-se que as duas terapias foram válidas no controle do edema e trismo, sendo a terapia combinada de dexametasona e meloxicam mais eficiente no controle da dor... (AU)

This Corticosteroids and anti-inflammatory non-steroidal drugs have been used in the search control inflammation of patients submitted to dental surgery. The goalwastoevaluate the effect of exclusive use of dexamethasoneandcombinationofdexamethasoneandmeloxicam in control of edema, trismus and pain following the extraction of impacted third molars (3MI). Fifteen healthy patients with indication for removal third molars in symmetricalpositionswereselected, dividedbydrawlot in therapeuticgroups (GT). In group1 (GT1), received a single oral dose of dexamethasone 12 mg one hour before the surgical procedure; in group 2 (GT2), oral dose of dexamethasone 12 mg one hour beforesurgery, and oral dose of 15 mg of meloxicamimmediatelypostoperative oral, at 24, 48 e 72h following surgery. At 24, 48 and 72 h following surgery, swelling was determine dusing linear measurement son the face andtrismus, by maximal mouth opening. Postoperative pain was self-recorded by patientsusing a visual analoguescale (VAS). Data analysisinvolved t-studentte stand Levenetest (p <0.05). Edema measures and trismus showed no statistically significant differences. The combination the rapeuticresulted in less pain with statistically significant difference. In conclusion, both the rapieswerevalids in controlling edema andtrismus, and combination the rapeutic more effective in pain control... (AU)