Osteosarcoma of the Clavicle in an Adolescent Child.

Clavicle is an unusual site for any primary bone tumour, including osteogenic sarcoma. Although a rare site of affection, most clavicular tumours tend to be malignant. We present a case report of osteosarcoma of the clavicle in a twelve-year-old male child who presented with a huge swelling of the left clavicle for the last six months.

Sudden death: Following metastasis from carcinoma of breast.

We report a case on sudden death brought to the Department of Forensic Medicine, Gauhati medical college, Assam. Death was due to syncope as a result of cardiac tamponade due to pericardial effusion following metastasis from carcinoma of breast. Death from cardiac tamponade following carcinoma breast is not a usual finding on the autopsy table. These sudden deaths make forensic pathologists aware of the course of natural diseases. Cardiovascular diseases accounts for vast majority of cases and certain neoplasm may also present as sudden death. Malignancy of breast is one of the commonest malignancies in females and often it presents late with metastasis to the underlying organs. The importance of autopsy lies here in the fact that it alleviates the doubts in the minds of the relatives of the deceased and relieves the law of the burden of un-necessary investigations. Moreover, role of pathology in Forensic Medicine in such cases is inevitable in establishing the cause of death.

Orchidectomy versus Orchidectomy plus cyproterone acetate in the treatment of metastatic prostatic carcinoma

This study included 42 patients all underwent orchidectomy and only 22 received cyproterone acetate in a dose of 150-200 mg PO daily. Clinical, laboratory and radiological evaluations were done during the period of the study [from January 1992 to June 1997 inclusive]. There was no high difference in the causes of death. The mean overall survival was longer in the combined treatment group [44.9 m vs. 36.9 m]. Time to disease progression was significantly longer in the combined modality group [30.7 m vs. 22.7 m]. Hot flushes were less in the combined group [31.0% vs. 60.6%] but the difference was insignificant

Gammapatía monoclonal asociada a carcinoma metastásico / Monoclonal gammapathy associated with metastatic carcinoma

Se informa una paciente con neoplasia no linfomatosa asociada a gammapatía monoclonal. Este hallazgo ha sido informado por diferentes autore, pero su implicación continúa sujeta a discrepancias. Se revisan los elementos diferenciales entre el mieloma múltiple y la aparición de inmunoglobulina monoclonal en pacientes con neoplasias no reticulares; se exponen los criterios sobre esta asociación