RESUMO
BACKGROUND: Primary non-gestational uterine cervical choriocarcinoma is very unusual and although it has been hypothesized that it can arise by metaplastic transformation of cervical epithelium, solid evidence has been lacking. CASE: Primary non-gestational uterine cervical choriocarcinoma was diagnosed in a 47-year-old, woman undergoing tubal resection 17 years previously. A histologically- and immunohistochemically-confirmed, non-gestational cervical choriocarcinoma could be diagnosed in which there was metaplastic transformation from squamous cells . The patient underwent 5 courses of an actinomycin-D chemotherapeutic regimen and radical hysterectomy with bilateral pelvic lymphadenectomy. CONCLUSION: Primary non-gestational uterine cervical choriocarcinoma may indeed arise from metaplastic transformation of epithelial tissue.
Assuntos
Antibióticos Antineoplásicos/uso terapêutico , Carcinoma de Células Escamosas/patologia , Transformação Celular Neoplásica , Coriocarcinoma não Gestacional/tratamento farmacológico , Dactinomicina/uso terapêutico , Feminino , Humanos , Histerectomia , Excisão de Linfonodo , Metaplasia/tratamento farmacológico , Pessoa de Meia-Idade , Neoplasias Pélvicas/cirurgia , Neoplasias do Colo do Útero/tratamento farmacológicoRESUMO
Adult male rats were exposed to cigarette smoke [2x/day/6 wks] in locally prepared chamber with an objective to study the effect of daily smoke exposure on body weight gain and possible epithelial changes encountered in the respiratory air-ways in conjunction with oral intake of 300 IU [2x/wK/6wK] of retinol palmitate. The exposure to cigarette smoke caused a significant [P<0.01] decrease in body weight gain relative to sham exposed animals, while the oral retionl intake had improved the gain over sham-treated. Analysis of serum retinol levels revealed a significant [P<0.001] decrease in the smoke-exposed rats relative to sham exposed rats. The epithelial changes of the larynx were the most prominent changes of the respiratory airways which varied from pseudostratified columnar ciliated epithelia to squamous metaplasia in the smoke-exposed rats while in those supplemented with the retinol, the laryngeal epithelia was nearly that of the sham-exposed and there was no sign of squamous metaplasia. Apparently, the retinol supplementation during cigarette smoke exposure might had a prophylactic role in human against unwanted cellular changes of the respiratory airways