Investigation and analysis of health-related quality of life in myasthenia gravis patients with myasthenia gravis quality of life-15 Chinese version / 北京大学学报(医学版)

OBJECTIVE@#To investigate the level and influencing factors of health-related quality of life in myasthenia gravis (MG) patients with myasthenia gravis quality of life-15 (MGQOL-15) Chinese version and to provide corresponding measures in one tertiary hospital of Sichuan Province.@*METHODS@#We collected the general data (gender, age, body mass index BMI, marital status, educational level and employee status), clinical data [Osserman type, myasthenia gravis composite (MGC), other immunopathies, disease duration, frequency of outpatient visits per month, ratio of disease cost to income each month and frequency of symptoms during the past month] and the MGQOL-15 Chinese version from 168 myasthenia gravis patients in one tertiary hospital of Sichuan Province.@*RESULTS@#The mean score of MGQOL-15 was 17.67±12.78. The score of the item "My occupational skills and job status have been negatively affected." was the highest, followed by "I have trouble using my eyes." and "I am frustrated by my MG." Single factor analysis showed that MG patients' QOL were different with different disease severity MGC (F=19.353, P<0.001), ratio of disease cost to income each month (F=5.831, P<0.001) and the frequency of symptoms during the past month (F=9.128,P<0.001). Multiple regression analysis showed that disease severity MGC (β=0.743,P<0.001), ration of disease cost to income each month (β=3.347,P<0.001) and the frequency of symptoms during the past month (β=2.216,P<0.003) were the main predictors of HRQOL in the MG patients.@*CONCLUSION@#Our study showed that the MGQOL-15 is helpful for clinicians to evaluate MG patients' QOL regularly, investigate the influencing factors and implement corresponding interventions the so as to improve the patients' quality of life. Disease severity MGC, ratio of disease cost to income each month and the frequency of symptoms during the past month were the main predictors of MG patients' QOL. Clinicians should pay more attention to MG patients' disease severity MGC and the frequency of symptoms during the past month.

Determinants of quality of life in Brazilian patients with myasthenia gravis

OBJECTIVES: The aims of the current study were 1) to evaluate the reliability and validity of the Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale and 2) to investigate the quality of life of Brazilian patients with myasthenia gravis and its determinants. METHODS: This cross-sectional study included 69 patients with myasthenia gravis who underwent neurological evaluation and completed questionnaires regarding quality of life (the 36-item Short Form of the Medical Outcomes Study and the 15-item Myasthenia Gravis Quality of Life Scale), anxiety and depressive symptoms. RESULTS: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale showed high internal consistency and good concurrent validity with the 36-item Short Form of the Medical Outcomes Study and its subscales. Determinants of quality of life in Brazilian patients with myasthenia gravis included the current status of myasthenia gravis as assessed by the Myasthenia Gravis Composite, the current prednisone dose and the levels of anxiety and depression. CONCLUSION: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale is a valid instrument. Symptom severity, prednisone dosage and anxiety and depression levels impact the quality of life of patients with myasthenia gravis.

Brazilian cross-cultural translation and adaptation of the "Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items" / Traducao e adaptacao transcultural do "Questionario de Qualidade de Vida Especifico para Miastenia Gravis 15 itens" para o Brasil

Objective To translate and to perform the cross-cultural adaptation of the “Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items” (MG-QOL15). Method The original English version of the questionnaire was translated into Portuguese. This version was revised and translated back into English. Later, both English versions were compared and the divergences were corrected in the Portuguese text. At a second stage, ten patients with MG followed at the Neuromuscular Diseases Clinic from the University Hospital, Universidade Federal de Minas Gerais answered the questionnaire. The authors analyzed the difficulties and misunderstandings in the application of the questionnaire. Results The questions 8, 13 and 15 were considered difficult to understand and were modified in the final Portuguese version. Most patients (70%) had a total score above 25, and the statements 3, 8 and 9 showed the highest scores. Conclusion The Brazilian version of the questionnaire MG-QOL15 seems to be a promising tool for the assessment of Brazilian patients with MG. .

Objetivo Realizar a tradução e a adaptação transcultural do “Questionário de Qualidade de Vida Específico para Miastenia Gravis – 15 itens” (MG-QOL15). Método Inicialmente, foi realizada a tradução do instrumento original em inglês para o português. Esta versão foi revisada e retrotraduzida para o inglês. A versão retrotraduzida foi comparada à versão original em inglês, sendo corrigidas as divergências no texto em português. Em um segundo momento, dez pacientes com MG acompanhados na Clínica de Doenças Neuromusculares do Hospital das Clínicas da Universidade Federal de Minas Gerais responderam ao questionário. Na aplicação do questionário, os itens mal compreendidos foram analisados pelos autores. Resultados Os itens 8, 13 e 15 foram considerados de difícil compreensão e modificados na versão final em português. A maioria dos pacientes (70%) apresentou uma pontuação total superior a 25, sendo que os itens 3, 8 e 9 apresentaram os escores mais elevados. Conclusão A versão brasileira do MG-QOL15 é um instrumento promissor para a avaliação de pacientes brasileiros com MG. .

Psychiatric disorders in myasthenia gravis / Transtornos psiquiátricos na miastenia gravis

OBJECTIVE: To investigate the prevalence of psychiatric disorders in patients with myasthenia gravis (MG). METHOD: Forty-one patients with MG answered to a structured psychiatric interview (MINI-Plus). RESULTS: Eleven (26.1 percent) patients were diagnosed with a depressive disorder and 19 (46.3 percent) were diagnosed with an anxiety disorder. Patients with dysthymia were older (p=0.029) and had longer disease duration (p=0.006). Patients with social phobia also had longer disease duration (p=0.039). CONCLUSION: Psychiatric disorders in MG are common, especially depressive and anxiety disorders.

OBJETIVO: Investigar a prevalência de transtornos psiquiátricos em pacientes com miastenia gravis (MG). MÉTODO: Quarenta e um pacientes com MG responderam a uma entrevista psiquiátrica estruturada (MINI-Plus). RESULTADOS: Onze (26,1 por cento) pacientes foram diagnosticados com transtorno depressivo e 19 (46,3 por cento) foram diagnosticados com um transtorno de ansiedade. Pacientes com distimia eram mais velhos (p=0,029) e tinham maior tempo de doença (p=0,006). Os pacientes com fobia social também tiveram maior tempo de doença (p=0,039). CONCLUSÃO: Transtornos psiquiátricos na MG são bastante comuns, principalmente transtornos depressivos e de ansiedade.

Influência da terapêutica sobre a qualidade de vida do paciente com mistenia grave / Doutor

Introdução: A miastenia gravis (MG) adquirida é uma desordem neuromuscular, que dificulta a transmissão do impulso nervoso e provoca fadiga e fraqueza flutuantes na musculatura ocular, facial, dos membros e respiratória.Casuística: Foram avaliados 51 pacientes com MG, 38 submetidos a tratamento conservador e 13 timectomizados. Métodos: Os instrumentos de QV como Whoqol, qualidade de vida relacionada à saúde (QVRS) SF-36, e depressão ( BDI) foram utilizados.Estatística: Na análise univariada :Wilcoxon, U-Mann-Whitney, Fisher e razão de chance; e na análise multivariada a interação de múltiplos fatores.Resultados: Não houve diferenças significantes entre as terapêuticas em relação aos aspectos clínicos, QV, QVRS e Depressão, através da análise univariada / bem estar nos pacientes...

Introduction: Myasthenia gravis (MG) is an immune mediated neuromuscular disease and orders in nervous impulse transmission. The disease´s clinical characteristics include fatigability and fluctuating weakness of voluntary muscles. Objective: To evaluate the influence of conservative treatment and thymectomy on Qol and clinical response of myasthenic patients.Subjects: Fifty-one myasthenic patients were chosen ; 38 were submitted to conservative therapy and 13 to thymectomy. Methods: Quantitative Qol tools such as Whoqol, SF-36 and BDI were employed to evaluate Qol, HRQol and depression.Statistics: Univariate analysis: Wilcoxon, U-Mann Whitney Fisher tests, Chi-Square.Discriminant analysis was used to analyze the interation of multiple factors.Results: There was no differences between therapeutics groups concerning clinical progress, QoL, HRQoL and depression.The evaluation of multiple parameters pointed to a strong and positive influence of thymectomy in the recovery of the patients...