RESUMO
In the present work, the effect of Apresoline on the myocardium and on the renal cortex of adult 18 male balady rabbits was reported. Administration of Apresoline in group 1: that received 5 mg / kg bw daily for 3 days produced sever effect on the heart in the form of wide separation between the muscle fivers, extravasated blood, wide areas of loss of striations and lysis of the myofibrils. When the drug was given in the therapeutic dose [0.5 mg / kg Bw] the effect of the drug increased progressively with the increase in the duration of intake. In group 2: that received the during for 2 weeks, some cardiac muscle fibers showed slight degeneration in the form of loss of striations, which were replaced by granular formation. Few mitochondria were degenerated. In group 3: that received Apresoline for 4 weeks, marked degeneration in the myofibrils in the form of wide areas of loss of striations that were replaced by granular formation were obvious. The sarcoplasm showed degenerated and elongated mitochondria, as well as autophagosomes and dense bodies. Also extravasted blood between the muscle fibers was apparent. The renal cortex suffered also from the treatment with Apresolin, but to a lesser degree than the heart. In group 1: Many proximal convoluted tubules were edematous with obliteration of their lumina and other were degenerated, but the distal tubules and the renal corpuscles appeared normal. In group 2: there were some inflammatory cells, little widening the capsular space and some proximal tubules were slightly dilated. In group 3: some renal corpuscles were degenerated with marked widening in the capsular spaces. Many proximal tubules were dilated with partial loss of their brush borders. Also, extravasated blood and degenerated mitochondria were prominent