Multiple dermatomyofibromas

Abstract: This study describes a case of a 19-year-old patient with seven asymptomatic lesions on the chest, measuring between 0.5 to 1cm in diameter, with no history of trauma in the region. The immunohistochemical evaluation was positive for vimentin and smooth muscle actin, determining Dermatomyofibroma as definitive diagnosis. Dermatomyofibroma is a benign skin tumor, with a myofibroblastic origin, prevalent in young women. It usually presents as a single lesion, with very few reports of multiple lesions.

Intraosseous myofibroma of the mandible: a case report / Miofibroma intraoseo mandibular: reporte de caso

The myofibroma is defined as a benign neoplasm formed by myoid contractile cells localized around the wall of thin blood vessels, it is a tumor that presents itself mostly in infancy although it may occur at any age and it is most common in head and neck; it is uncommon to be localized in the oral cavity and even less common if it is intraosseous. It may also be associated to miofibromatosis or present itself as a solitary lesion. The differential diagnosis depends on the localization and the radiographic characteristics; it would be very difficult to include, at first hand, myofibroma as an intraosseous lesion. Histopathologically, a neoplasm with a biphasic pattern formed by spindle cells in fascicles and bundles, spindle nucleus with eosinophilic cytoplasm inside a hyalinized stroma was found. In lesions of neoplasms of spindle cells histological studies should be supported by an immunohistochemical panel and show positive results to antibodies Actin, smooth muscle Actin and Vimentin.

El miofibroma es una neoplasia benigna compuesta por células mioides contráctiles localizadas alrededor de la pared de vasos sanguíneos delgados, es un tumor que se presenta sobre todo en la infancia aunque puede ocurrir a cualquier edad, tiene predilección en cabeza y cuello, sin embargo en cavidad oral es raro y aún más si es intraóseo, puede estar asociado a miofibromatosis o bien presentarse de manera solitaria. Los diagnósticos diferenciales dependen de la localización y de las características radiográficas y de primera instancia es muy difícil incluir al miofibroma entre las lesiones intraóseas. Histológicamente presenta patrón bifásico conformado por células fusiformes dispuestas en fascículos y haces así como núcleos fusiformes con citoplasma eosinófilo dentro de un estroma hialinizado. Es necesario recurrir al panel de inmunohistoquímica en neoplasias de células fusiformes, positivo a Acs Actina, Actina músculo liso y Vimentina. Reportamos el caso de una mujer de 45 años con un miofibroma en la mandíbula.

Dermatomiofibroma: relato de caso de doença rara / Dermatomyofibroma: a case report of a rare disease

O Dermatomiofibroma está incluído no grupo de lesões neoplásicas mesenquimais benignas de linhagem fibroblástica e miofibroblástica da pele. É uma doença rara, havendo aproximadamente 100 casos descritos na literatura mundial até o momento. Este artigo relata o caso de uma mulher jovem com apresentação clínica típica e diagnóstico histopatológico de dermatomiofibroma. Foram realizadas colorações especiais que mostraram preservação das fibras colágenas e a imunohistoquímica revelou positividade para vimentina e negatividade para actina e S100. Por se tratar de doença rara, os achados histopatológicos são de grande importância, mas a supeição clínica é possível em casos típicos como este.

Dermato myofibroma is included in the group of benign cutaneous mesenchymal neoplastic lesions of fibroblastic and myofibroblastic lineage. It's a rare disease and there are approximately only one hundred cases described worldwide in the medical literature up to now. The present study reports the case of a young woman with typical clinical cutaneous lesion and histopathological diagnosis of dermato myofibroma. Special stains were carried out which showed preserved collagen fibers and immunohistochemistry was positive for vimentin and negative for actin and S100. As it is a rare disease, the histopathological findings are of great importance but clinical suspicion is possible in typical cases such as this one.

Adult cutaneous myofibroma.

A 63-year-old male presented with an asymptomatic, slow-growing swelling on the right lower limb for the past one and half years. The histopathology revealed a lobular neoplasm with a biphasic pattern of spindle shaped cells and hemangiopericytoma like areas at the periphery of the lobule. The diagnosis of adult cutaneous myofibroma was made. This case highlights the importance of histopathology in reaching a definitive diagnosis.