Inflammatory markers, endothelial function and cardiovascular risk / Marcadores inflamatórios, função endotelial e riscos cardiovasculares

The need to study cardiovascular diseases (CVD) has become more and more relevant as their prevalence has increased over the years. An intact endothelial wall is essential to vascular health. Certain factors are responsible for maintaining this tissue intact, including nitric oxide (NO), which provokes dilation of blood vessels in response to shear stress. Expression of the endothelial nitric oxide synthase (eNOS) enzyme, which produces nitric oxide in response to increases in blood flow, is of fundamental importance to maintenance of the vascular system. When this enzyme is inhibited, nitric oxide production is reduced, causing endothelial dysfunction. Since C-reactive protein inhibits production of nitric oxide by the eNOS enzyme, it is one of the causes of endothelial dysfunction and cardiovascular events. The objective of the present study was to review scientific articles in the literature related to the subject 'inflammatory markers and endothelial function'. A wide-ranging review of the current literature was conducted, using systematic analysis of bibliographic references indexed in PubMed, Scielo, Medline and LILACS database, for the years 1992 to 2013. The studies reviewed show that increases in inflammation causes reductions in NO and increases in cardiovascular events. Increased inflammation is associated with higher incidence of cardiovascular diseases...

A necessidade de estudo das Doenças Cardiovasculares (DCV) vem à tona pelo aumento da sua prevalência ao longo dos anos. Uma parede endotelial íntegra é essencial para a saúde vascular. Alguns fatores são responsáveis pela integridade deste tecido, como o óxido nítrico (NO), que provoca a dilatação do vaso sanguíneo em resposta ao estresse de cisalhamento. A expressão da enzima óxido nítrico sintase endotelial (eNOS), que produz óxido nítrico em resposta ao incremento do fluxo sanguíneo, é fundamental para a manutenção do sistema vascular. Quando há inibição desta enzima, ocorre diminuição da produção de óxido nítrico, causando disfunção endotelial. A PCR inibe a produção de óxido nítrico pela enzima eNOS, sendo então uma causadora de disfunção endotelial e eventos cardiovasculares. O presente artigo tem como objetivo revisar artigos científicos na literatura relacionados ao tema 'marcadores inflamatórios e função endotelial'. Foi realizada uma ampla revisão de literatura atual, utilizando-se análise sistemática das referências bibliográficas nas bases de dados PubMed, Scielo, Medline e Lilacs, no período de 1992 a 2013. Os estudos revisados mostram que o aumento da inflamação causa uma diminuição de NO e aumento de eventos cardiovasculares. O aumento da inflamação está associado ao aumento da incidência de doenças cardiovasculares...

A review on recent development of common cold therapeutic agents.

(1) The common cold is a frequently occurring illness caused by rhinoviruses. Inspite of its ubiquitous occurrence the disease has defied all efforts of finding a cure. The current approaches to the treatment of common cold can be divided into two important categories: the antiviral and antiinflammatory; both of these leave a lot to be desired. Most of the rhinovirus serotypes use a single cellular receptor, i.e. the intercellular Adhesion Molecule-1 (ICAM-1) for attachment to the cells. This has lead to the development of blockers of this receptor in an effort to find a cure for the common cold. (2) Recently tremacarmra, a synthetic ICAM-1 glycoprotein has been investigated in human volunteers as an antiadhesion molecule towards an approach to common cold therapy. Two dosage forms of the compound-phosphate buffered saline spray and carboxymethyl cellulose-mannitol powder spray were administered intra-nasally in two modes--pre-inoculation (7 h prior) and post-inoculation (24 h after) time periods of rhinovirus type 39 challenge to different groups of human volunteers. Both the treatment modes produced a significant decrease in the symptoms score of clinical illness and concentration of interleukin-8 in the nasal lavage. Saline spray was found to be devoid of any side effects, whereas powder spray produced some nasal irritation initially. The encouraging results of clinical trial with tremacamra show that a cure for common cold is not far off. However, it remains to be seen what would be the impact of such synthetic protein administration on the immune response of the body, should such compounds be used repeatedly. Further, since all colds are not due to rhinovirus it would be wise to restrict the use of tremacamra during autumn and spring when rhinoviruses are known to be the causative organisms of common cold.