Stability study of tri-otic ear drop

The aim of this method is to study the stability of a potent Tri-Otic ear drop oily suspension non pharmacopoeia, as pharmaceutical dosage form four active ingredients. This ear drop consists from Triamcinolon acetonide as corticosteroid and Neomycin sulphate, Gramicidin as antibacterial agents as well as Nystatin as antifungal agent. This study based upon the accelerated stability study for many samples store at different temperatures 4, 25, 40°C, in amber colour glass containers for three months. The results were analyzed using HPLC technique for Triamcinolon acetonide degassing solution consists from highly purified water: acetonitril 30:70 [V/V%] as mobile phase with rate of flow 1.5 ml/ min, using ODS column. The spectrums were detected at 330 nm for maximum peak and area under the curve [AUC]. While biological methods used for analyzed both Neomycin sulphate and Nystatin. The media used for culture at 35-37°C for 7 days at pH 5.8-8 consist from potassium di hydrogen phosphate with sodium hydroxide for inhibition zone and applied biological assay. All active ingredients were extracted four times. From correlation between the concentration and time used by applying accelerated stability study data, according to the Arrhenius equation, we found the hydrolysis of oil suspension was pseudo first order K = Ln[2] /1 [0.5]. Our conclusion show that the Tri-Otic ear drop useful for two years approximately at 4°C

Farmacología clínica de los aminoglicósidos y los aminociclitoles en medicina veterinaria / Clinical pharmacology of aminoglycoside and aminocyclitol antibacterials in veterinary medicine

Dada la importancia de los aminoglicósidos y aminocilitoles en la clínica veterinaria, y en virtud de la enorme cantidad de información que se genera en torno a estos antimicrobianos, se consideró de importancia llevar a cabo un análisisi farmacológico y clínico de la literatura especializada. La intención primordial de realizar estudios documentales de esta naturaleza es estrechar las actividades del clínico con las del investigador para procurar un mejor manejo de estos medicamentos en el campo, aunque también se hace énfacis en las áreas que aún requieren atención de los investigadores. Este ensayo no pretende ser enciclopédico y solamente se incluye un porcentaje del enorme caudal de información que se genera con estos dos grupos de antimicrobianos. Se hace énfasis en los aspectos farmacológicos que pueden ser de importancia para el clínico, incluyendo rasgos generales de los grupos, datos farmacocinéticos, de espectro, residuos, toxicidad y usos. Cuando resulta neceario, se presenta la opinión de los autores