Adenoma silente subtipo 3: importancia del estudio ultraestructural en el diagnóstico diferencial del adenoma hipofisiario asociado a hiperprolactinemia en un caso / Silent pituitary adenoma type 3 associated to hyperprolactinemia: report of 1 case

The association of hyperprolactinemia over 100 ng/ml and a pituitary adenoma is usually diagnostic of prolactinoma. However type 3 pituitary adenomas can occur with similar serum prolactin values. We report a 31 years old woman that consulted due to headache and photopsiae. She had a serum prolactin level of 148 ng/ml and imaging studies showed a solid tumor that occupied the selar region and most of the left temporal fossa. The tumor was partially resected and the patient recovered her lost visual field. Light microscopy showed an acidophilic and in part chromophobe adenoma. Immuno-histochemistry was positive for prolactin and growth hormone. Electron microscopy disclosed features of a silent type 3 adenoma such as big cells with cytoplasmic prolongations, pleomorphic nuclei and a greatly developed rough endoplasmic reticulum

Oncocitoma hipofisiario: informe de un caso / Hypophyseal oncocytoma: report of a case

Los Oncocitomas Hipofisiarios son raros tumores que se presentan asemejando Adenomas no funcionantes de tipo eosinófilo y que ultraestructuralmente se caracterizan por la presencia en el citoplasma celular, de gran cantidad de mitocondrias polimorfas y de estructura atípica, que dan el aspecto a la microscopía de luz de células eosinófilas y de aspecto granular. Presentamos el caso de un paciente de 59 años, estudiado y tratado en el Instituto Neurológico de Colombia, por un adenoma no funcionante de hipófisis, que el estudio por microscopía electrónica presentó las características de un Oncocitoma Hipofisiario