RESUMO
The anticarcinogenic effects and mechanisms of the biotechnological drugs of Panax ginseng C.A. Meyer cultivated in Russia, bioginseng, panaxel and panaxel- 5, were studied. Bioginseng was produced from a tissue culture of ginseng root cultured on standard medium, whereas panaxel and panaxel-5 were produced from ginseng tissue root cultures using standard mediums enriched with 2-carboxyethylgermanium sesquioxide and 1-hydroxygermatran-monohydrate respectively. All three ginseng drugs inhibited the development of mammary tumors induced by intramammary injections of N-methyl-N-nitrosourea (MNU) in rats, the development of the brain and spinal cord tumors induced by transplacental administration of N-ethyl-N-nitrosourea (ENU) in rats, and the development of uterine, cervical and vaginal tumors induced by intravaginal applications of 7,12-dimethylbenz(a)anthracene (DMBA) in mice. The ginseng drugs induced the cytotoxic activity of macrophages in mice, enhanced T-lymphocyte rosette formation in guinea pigs exposed to cyclophosphamide, and stimulated the production of thyroid hormones in rats. These mechanisms may contribute to the anticarcinogenic action of the ginseng drugs. The organic germanium compounds present in panaxel and panaxel-5 did not potentiate the anticarcinogenic or immuno- stimulatory effects as much as biogeinseng. Preliminary clinical trials with panaxel and bioginseng were carried out in patients with precancerous lesions of the esophagus and endometrium. Panaxel was found to have a strong therapeutic effect in patients suffering from chronic erosive esophagitis. Bioginseng induced the regression of adenomatous-cystic hyperplasia of the endometrium in some patients. Thus, we conclude that the drugs of ginseng appear to hold considerable promise for future cancer chemoprevention.
Assuntos
Adulto , Feminino , Humanos , Masculino , Camundongos , Ratos , Adenocarcinoma/induzido quimicamente , Animais , Antineoplásicos Fitogênicos/uso terapêutico , Células Cultivadas , Neoplasias do Colo do Útero/induzido quimicamente , Ensaios Clínicos como Assunto , Testes Imunológicos de Citotoxicidade , Modelos Animais de Doenças , Neoplasias do Endométrio/patologia , Endométrio/patologia , Neoplasias Esofágicas/patologia , Esôfago/patologia , Estradiol/sangue , Fibroadenoma/induzido quimicamente , Macrófagos Peritoneais/citologia , Neoplasias Mamárias Experimentais/induzido quimicamente , Camundongos Endogâmicos C57BL , Neoplasias Experimentais/induzido quimicamente , Neoplasias do Sistema Nervoso/induzido quimicamente , Panax/metabolismo , Lesões Pré-Cancerosas/patologia , Técnicas de Cultura , Neoplasias Uterinas/induzido quimicamente , Neoplasias Vaginais/induzido quimicamenteAssuntos
Humanos , Feminino , Gravidez , História do Século XX , Dietilestilbestrol/efeitos adversos , Adenocarcinoma de Células Claras/induzido quimicamente , Brasil , Genitália Feminina/anormalidades , Genitália Feminina/patologia , Neoplasias do Colo do Útero/induzido quimicamente , Neoplasias Vaginais/induzido quimicamenteRESUMO
O adenocarcinoma de células claras de vagina e cérvice é um câncer raro. Aproximadamente 2/3 destas pacientes têm história positiva de exposiçäo intra-uterina ao dietilestilbestrol. A maioria das pacientes säo jovens e têm estágios iniciais e säo tratados com sucesso pela cirurgia pélvica radical. Um cuidadoso programa de investigaçäo e tratamento é proposto pelos autores