RESUMO
Cutaneous metastases originating from an internal cancer are relatively uncommon in clinical practice, and metastatic lesions to the breast are rarer than those to the skin. Skin metastases of lung cancer, which may be the first sign of the disease, usually indicate progressive disease and a poor prognosis. We describe a 47-year-old male who presented with recurring masses in the lumbar region bilaterally and the right breast. Immunohistochemical findings and radiological imaging suggested lung cancer. This is the first reported case of small cell lung cancer metastasizing to two separate, uncommon sites, the skin and breast.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Biópsia , Neoplasias da Mama Masculina/química , Evolução Fatal , Imuno-Histoquímica , Neoplasias Pulmonares/química , Neoplasias Cutâneas/química , Carcinoma de Pequenas Células do Pulmão/química , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Biomarcadores Tumorais/análiseRESUMO
50 cases of breast malignancy constituted the study group. 26 age and sex matched formed the control group. Serum and tissue trace element viz copper, zinc, selenium and molybdenum levels were estimated by atomic absorption photometry. The study group showed significant hypercupremia and molybdenemia, hypozincaemia and hyposeleniamia. The reversal of trend was documented after therapy. The tissue level of copper and molybdenum was high and zinc and selenium was low. An association between serum and tissue level of trace element, stage, histological differentiation was observed. It was postulated that levels of trace elements may help in diagnosis and prognosis of disease.